2. Gene
  3. Map4k2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

Map4k2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶激酶 kinase kinase 2

种属: Mus musculus

同用名: GCK; BL44; Rab8ip

基因 ID: 26412 | 基因类型: protein coding

关于 Map4k2

Chromosome 19: 6,391,165-6,405,645 forward strand.GRCm39:CM001012.3

This gene has 23 transcripts (splice variants), 101 orthologues and 35 paralogues. Broad expression in thymus adult (RPKM 169.4), spleen adult (RPKM 142.6) and 23 other tissues.

功能概要

预测该基因编码的蛋白可启动 ATP 绑定活动； MAP激酶激酶激酶活性；和有丝分裂原活化蛋白激酶激酶激酶结合活性。参与囊泡靶向。预测位于高尔基体和质膜。以多种结构表达，包括消化系统；脑;泌尿生殖系统；淋巴系统腺体；以及肝脏和胆道系统。与人 MAP4K2（丝裂原活化蛋白激酶激酶 kinase kinase 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in vesicle targeting. Predicted to be located in Golgi apparatus and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map4k2 基因产物(2)

mRNA Protein Name
NM_001291787.1 NP_001278716.1 mitogen-activated protein kinase kinase kinase kinase 2 isoform 2
NM_009006.3 NP_033032.1 mitogen-activated protein kinase kinase kinase kinase 2 isoform 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in vesicle targeting IDA
IDA: 通过直接分析推断
8643544 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Map4k2 蛋白结构

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (15 - 271)

CNH

CNH: smart00036 (488 - 800)

  • 0
  • 200
  • 400
  • 600
  • 821 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 2

MAPK/ERK kinase kinase kinase 2

MEK kinase kinase 2

MEKKK 2

RAB8 interacting protein

germinal center kinase

rab8-interacting protein

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15434 NG25 Inhibitor 99.35% 否
HY-148063 DB0614 98.80% 否
HY-123714 TL4-12 99.82% 否
HY-148061 DB1113 99.28% 否
HY-77251 TAK1/MAP4K2 inhibitor 1 Inhibitor 99.90% 否
HY-148065 FMF-06-098-1 / 否
HY-15434A NG25 trihydrochloride Inhibitor / 否
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08076 Map4k2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map4k2 NCBI NCBI:5871
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