Mapk1 - mitogen-activated protein kinase 1 Gene

中文名称：丝裂原活化蛋白激酶1

种属: Mus musculus

同用名: ERK; Erk2; MAPK2; PRKM2; Prkm1; p41mapk; p42mapk; 9030612K14Rik

关于 Mapk1

功能概要

该基因编码的蛋白可启动多种功能，包括相同的蛋白质结合活性；磷酸酪氨酸残基结合活性；和蛋白激酶活性。参与肽基丝氨酸磷酸化；肽基-苏氨酸磷酸化；和对尼古丁的反应。作用于多个过程的上游或内部，包括动物器官发育；细胞表面受体信号通路；和细胞对细胞因子刺激的反应。位于几种细胞成分中，包括细胞质；线粒体；和伪讲台。以多种结构表达，包括消化系统；早孕;泌尿生殖系统；神经系统;和感觉器官。用于研究Weissenbacher-Zweymuller综合征；自闭症谱系障碍；和腭心面综合征。该基因的人类直系同源物与努南综合征 13 相关；腺癌（多发性）；肺动脉高压;和肾细胞癌。与人 MAPK1（丝裂原活化蛋白激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein kinase activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and response to nicotine. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and cellular response to cytokine stimulus. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]