Mapk10 - mitogen-activated protein kinase 10 Gene

中文名称：丝裂原活化蛋白激酶 10

种属: Mus musculus

同用名: JNK3; Serk2; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); C230008H04Rik

关于 Mapk10

功能概要

该基因编码的蛋白质是 MAP 激酶家族的成员。 MAP 激酶充当多种生化信号的整合点，因此参与多种细胞过程，例如增殖、分化、转录调控和发育。这种激酶在神经系统的一部分神经元中特异性表达，并被苏氨酸和酪氨酸磷酸化激活。在小鼠中靶向删除该基因表明它可能在应激诱导的神经细胞凋亡中起作用。已发现该基因编码不同亚型的可变剪接转录物变体。最近的一项研究为该基因的翻译通读提供了证据，并通过使用替代的框内翻译终止密码子表达了额外的 C 末端扩展同种型。 [RefSeq 提供，2017 年 12 月]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]