2. Gene
  3. GCNT1 - glucosaminyl (N-acetyl) transferase 1 Gene

GCNT1 - glucosaminyl (N-acetyl) transferase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：氨基葡萄糖 (N-乙酰基) 转移酶 1

种属: Homo sapiens

同用名: G6NT; C2GNT; C2GNT1; NACGT2; NAGCT2; C2GNT-L; C2GlcNAcT

基因 ID: 2650 | 基因类型: protein coding

关于 GCNT1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:76,441,666-76,507,416 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 20.0), stomach (RPKM 13.9) and 13 other tissues.

功能概要

该基因是 β-1,6-N-乙酰葡糖胺基转移酶基因家族的成员。它对于 Gal beta 1-3 (GlcNAc beta 1-6) GalNAc 结构和核心 2 O-聚糖分支的形成至关重要。编码该酶的基因最初定位于 9q21，但后来定位于 9q13。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this Enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GCNT1 基因产物(9)

mRNA Protein Name
NM_001097633.2 NP_001091102.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097634.1 NP_001091103.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097635.2 NP_001091104.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097636.2 NP_001091105.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407181.1 NP_001394110.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407182.1 NP_001394111.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407183.1 NP_001394112.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407184.1 NP_001394113.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001490.5 NP_001481.2 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23027862 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in O-glycan processing, core 2 IDA
IDA: 通过直接分析推断
1329093 GOA
involved in cell adhesion molecule production IMP
IMP: 通过突变表型推断
23027862 GOA
involved in glycoprotein biosynthetic process IMP
IMP: 通过突变表型推断
23027862 GOA
involved in leukocyte tethering or rolling IMP
IMP: 通过突变表型推断
23027862 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi cisterna IDA
IDA: 通过直接分析推断
23027862 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
23027862 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GCNT1 蛋白结构

Branch

Branch: Core-2/I-Branching enzyme (123 - 391)

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  • 428 a.a.
蛋白主名 其他名称

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

beta-1,6-N-acetylglucosaminyltransferase

GCNT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GCNT1 Q02742 GOLPH3 Homo sapiens Q9H4A6
Y2H
23027862
种属内
GCNT1 Q02742 GOLPH3 Homo sapiens Q9H4A6
Pull Down
23027862
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05339 GCNT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GCNT1 RGD RGD:621370
Canis familiaris GCNT1 VGNC VGNC:54843
Mus musculus GCNT1 MGD MGI:95676
Bos taurus GCNT1 VGNC VGNC:56968
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