GFRA2 - GDNF family receptor alpha 2 Gene

中文名称：GDNF 家族受体 alpha 2

种属: Homo sapiens

同用名: NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA

关于 GFRA2

功能概要

神经胶质细胞源性神经营养因子 (GDNF) 和神经营养因子 (NTN) 是两种结构相关的强效神经营养因子，在控制神经元存活和分化中起着关键作用。该基因编码的蛋白质是 GDNF 受体家族的成员。它是 GDNF 和 NTN 的糖基磷脂酰肌醇 (GPI) 连接的细胞表面受体，并介导 RET 酪氨酸激酶受体的激活。与其其他家族成员 GDNF 家族受体 alpha 1 相比，这种编码的蛋白质优先充当 NTN 的受体。该基因是 RET 相关疾病的候选基因。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 9 月]

Glial cell line-derived neurotrophic factor (GDNF) and Neurturin (NTN) are two structurally related, potent Neurotrophic Factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF Receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its Other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]