1. Gene
  2. HAVCR1 - hepatitis A virus cellular receptor 1 Gene

HAVCR1 - hepatitis A virus cellular receptor 1 Gene

中文名称:甲型肝炎病毒细胞受体 1

种属: Homo sapiens

同用名: TIM; KIM1; TIM1; CD365; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1

基因 ID: 26762 | 基因类型: protein coding

关于 HAVCR1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,029,413-157,069,407 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 3 paralogues. Biased expression in kidney (RPKM 1.3), colon (RPKM 1.2) and 6 other tissues.

功能概要

该基因编码的蛋白质是人类甲型肝炎病毒 (HHAV) 和 TIMD4 的膜受体。所编码的蛋白质可能与哮喘和过敏性疾病的缓解有关。参考基因组代表保留 MTTVP 氨基酸片段的等位基因,该氨基酸片段赋予 HHAV 血清阳性个体特应性保护。该蛋白是多种其他病毒的受体,包括埃博拉病毒、马尔堡病毒、登革病毒和寨卡病毒,并且可能是 SARS-CoV-2 和其他冠状病毒的进入因子。[RefSeq 提供,2021 年 9 月]

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple Other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and Other coronaviruses. [provided by RefSeq, Sep 2021]

HAVCR1 基因产物(3)

mRNA Protein Name
NM_001173393.3 NP_001166864.1 hepatitis A virus cellular receptor 1 isoform a precursor
NM_001308156.2 NP_001295085.1 hepatitis A virus cellular receptor 1 isoform b precursor
NM_012206.3 NP_036338.2 hepatitis A virus cellular receptor 1 isoform a precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32995803 GOA
enables virus receptor activity IDA
IDA: 通过直接分析推断
21536871 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in motile cilium IDA
IDA: 通过直接分析推断
21536871 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HAVCR1 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (26 - 111)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

hepatitis A virus cellular receptor 1

T cell immunoglobin domain and mucin domain protein 1

HAVCR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
HAVCR1 Q96D42 S SARS-CoV-2 P0DTC2
Anti Bait CoIP
33493263
种属间
HAVCR1 Q96D42 S SARS-CoV-2 P0DTC2
MST
32995803
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HAVCR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73604 TIM-1/KIM-1/HAVCR Protein, Human (HEK293, His-Fc) AAC39862 (S21-G290) ≥95%
HY-P73605 TIM-1/KIM-1/HAVCR Protein, Human (HEK293) AAC39862 (S21-G290) ≥95%
HY-P73606 TIM-1/KIM-1/HAVCR Protein, Human (270a.a, HEK293, His) AAC39862 (S21-G290) ≥95%
HY-P73607 TIM-1/KIM-1/HAVCR Protein, Human (135a.a, HEK293, His) AAC39862 (S21-V135) ≥95%

关联疾病

疾病名称 别名
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Hepatitis A

Viral Hepatitis A

Viral Hepatitis, Type A

Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Acute Kidney Tubular Necrosis

Acute Tubular Necrosis

Acute Renal Failure With Tubular Necrosis

Acute Tubule Necrosis

Acute Renal Failure With Lesion Of Tubular Necrosis

Atn - Acute Tubular Necrosis

Tubular Necrosis Acute

Kidney Tubular Necrosis, Acute

Acute Renal Tubular Necrosis

Acute Tubular Nephrosis

Ischaemic Acute Tubular Necrosis

Ischaemic Tubular Necrosis

Kidney Tubular Necrosis

Lower Nephron Nephrosis

Necrotising Renal Oedema

Renal Tubular Necrosis

Toxic Tubular Necrosis

Tubular Kidney Necrosis

Tubular Necrosis Nos

Tubular Nephrosis

Allergic Asthma

Atopic Asthma

Extrinsic Asthma

Extrinsic Asthma With Acute Exacerbation

Extrinsic Asthma With Status Asthmaticus

Asthma Allergic

Atopic Asthma, Susceptibility To

Ige-Mediated Allergic Asthma

Allergen-Induced Asthma

Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma

Allergic Asthma Nos

Catarrh With Asthma

Allergic Bronchitis Nos

Extrinsic Allergic Asthma

Predominantly Allergic Asthma With Stated Status Asthmaticus

Scrub Typhus

Tsutsugamushi Disease

Tsutsugamushi Fever

Typhus Fever Due To Rickettsia Tsutsugamushi

Chigger-Borne Rickettsiosis

Chigger-Borne Typhus

Japanese River Fever

Kedani Fever

Mite-Borne Rickettsiosis

Mite-Borne Typhus

Scrub Typhus

Scrub Mite-Borne Typhus

Tropical Typhus

Tsutsugamushi

Allergic Rhinitis

Hay Fever

Allergic Rhinitis, Susceptibility To

ALRH

Atopic Rhinitis

Seasonal Allergic Rhinitis

Non-Seasonal Allergic Rhinitis

Perenial Allergic Rhinitis

Pollenosis

Rhinitis Allergic Seasonal

Rhinitis, Allergic, Perennial

Allergic Rhinitis, Cause Unspecified

Pollinosis

Pollen Allergy

Allergy Nos Due To Pollen

Summer Catarrh

Other Seasonal Allergic Rhinitis

Ventricular Tachycardia, Catecholaminergic Polymorphic, 4

Catecholaminergic Polymorphic Ventricular Tachycardia 4

CPVT4

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Cvpt4

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Vtsip

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 4

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Pyuria

Pus Cells In Urine

Type 1 Diabetes Mellitus 19

Diabetes Mellitus, Insulin-Dependent, 19

IDDM19

T1D19

Insulin-Dependent Diabetes Mellitus 19

Hyperuricemia

Blood Urate Raized

Uricacidemia

Congenital Anomalies Of Kidney And Urinary Tract 2

CAKUT2

Ureteropelvic Junction Obstruction

Multicystic Renal Dysplasia, Bilateral

Pelviureteric Junction Obstruction

Pujo

Hydronephrosis Due To Pujo

Upjo

Mcrd

Congenital Anomalies Of The Kidney And Urinary Tract 2

Mrd

Pelvi-Ureteric Junction Obstruction

Kidney And Urinary Tract, Anomalies, Congenital, Type 2

Obstruction Of Pelviureteric Junction

Cholesterol Embolism

Atheroembolism

Trash Foot

Cholesterol Crystal Embolism

Purple Toe Syndrome

Warfarin Blue Toe Syndrome

Embolism, Cholesterol

Cholesterol Embolus Syndrome

Ureteral Disease

Ureteral Diseases

Ureteral Disorders

Disorder Of Ureter

Urinary Tract Obstruction

Obstructive Uropathy

Urinary Obstruction

Urologic Diseases

Acute Kidney Failure

Acute Renal Failure

Acute Kidney Injury

Renal Failure Acute

Kidney Failure, Acute

Pre-Renal Acute Kidney Injury

Nontraumatic Acute Kidney Injury

Aki - [Acute Kidney Injury]

Arf - [Acute Kidney Failure]

Acute Kidney Disease

Acute Kidney Impairment

Acute Ischaemic Renal Failure

Acute Hypoxic Kidney Failure

Acute Kidney Shutdown

Acute Renal Oedema

Acute Renal Impairment

Acute Kidney Collapse

Acute Necrotising Kidney

Acute Renal Suppression

Interstitial Nephritis

Nephritis, Interstitial

Renal Tubulo-Interstitial Disease

Nephritis Interstitial

Nephritis, Tubulointerstitial

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Anuria

Suppression Of Urinary Secretion

Kidney Papillary Necrosis

Necrotizing Renal Papillitis

Papillary Necrosis

Renal Papillitis Necrotizing

Hepatorenal Syndrome

Hepato-Renal Syndrome

Hepatorenal Failure

Hrf - [Hepatorenal Failure]

Hepatorenal Degeneration

Hepatic Renal Syndrome

Hepatic Renal Failure

Renal Hepatic Failure

Urohepatic Syndrome

Obstructive Nephropathy

Con

Congenital Obstructive Nephropathy

Nephropathy Obstructive

Inflammatory Bowel Disease 14

IBD14

Inflammatory Bowel Disease 14, Susceptibility To

Bowel Disease, Inflammatory, Type 14

Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Kidney Hypertrophy

Hypertrophy Of Kidney

Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

Catecholaminergic Polymorphic Ventricular Tachycardia 3

CPVT3

Cvpt3

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3

Pyelitis
Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti

Congenital Granular Cell Tumor
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst

Fanconi Syndrome

Infantile Nephropathic Cystinosis

Adult Fanconi Syndrome

Congenital Fanconi Syndrome

De Toni-Fanconi Syndrome

Fanconi-De Toni Syndrome

Lignac-Fanconi Syndrome

Fanconi Renotubular Syndrome

Primary Fanconi Renotubular Syndrome

De Toni-Debre-Fanconi Syndrome

Adult Fanconi Anemia

Detoni Fanconi Syndrome

Fanconi-De-Toni Syndrome

Primary Fanconi Syndrome

Detoni-Debre-Fanconi Syndrome

Primary Fanconi Renal Syndrome

Fanconi Anemia

Cystinosis, Infantile Nephropathic

Fanconi-Bickel Syndrome

Renal Fanconi Syndrome

Lowe-Bickel Syndrome

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HAVCR1 RGD RGD:708425
Mus musculus HAVCR1 MGD MGI:2159680
Canis familiaris HAVCR1 NCBI NCBI:612069
Macaca fascicularis HAVCR1 NCBI NCBI:102141332
Others HAVCR1 NCBI