DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

中文名称：dickkopf WNT 信号通路抑制因子 3

种属: Homo sapiens

同用名: RIG; CRRL; REIC

基因 ID: 27122 | 基因类型: protein coding

关于 DKK3

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,963,036-12,009,745 (from NCBI)

This gene has 17 transcripts (splice variants) and 266 orthologues. Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues.

功能概要

该基因编码的蛋白质是 dickkopf 家族的一员。分泌的蛋白质包含两个富含半胱氨酸的区域，并通过与 Wnt 信号通路的相互作用参与胚胎发育。该基因的表达在多种癌细胞系中降低，可能起到抑癌基因的作用。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of Cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

DKK3 基因产物(4)

mRNA	Protein	Name
NM_001018057.2	NP_001018067.1	dickkopf-related protein 3 isoform 1 precursor
NM_001330220.3	NP_001317149.1	dickkopf-related protein 3 isoform 2 precursor
NM_013253.5	NP_037385.2	dickkopf-related protein 3 isoform 1 precursor
NM_015881.6	NP_056965.3	dickkopf-related protein 3 isoform 1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adrenal gland development	IEP IEP: 通过表达模式推断	12844346	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	16981135	GOA
involved in negative regulation of aldosterone biosynthetic process	IDA IDA: 通过直接分析推断	16981135	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	12857724	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	23538390	GOA
involved in negative regulation of cortisol biosynthetic process	IDA IDA: 通过直接分析推断	16981135	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DKK3 蛋白结构

Dickkopf_N

0
100
200
300
350 a.a.

蛋白主名

其他名称

dickkopf-related protein 3

RIG-like 5-6

重组 DKK3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7812	DKK-3 Protein, Human (HEK293, His)	Q9UBP4 (A22-I350)	≥95%
HY-P77640	DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9UBP4 (P23-I350)	≥95%
HY-P78681	DKK-3 Protein, Human (R335G, HEK293, His)	Q9UBP4 (A22-I350, R335G)	≥95%

关联疾病

疾病名称

别名

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Ventricular Tachycardia, Catecholaminergic Polymorphic, 4

Catecholaminergic Polymorphic Ventricular Tachycardia 4	CPVT4
Bidirectional Tachycardia	Stress-Induced Polymorphic Ventricular Tachycardia
Cvpt4	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Vtsip
Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 4	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Witkop Syndrome

Tooth And Nail Syndrome	Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome
Tns	Ectodermal Dysplasia 3, Witkop Type
ECTD3	Ectodermal Dysplasia 3, Tooth/Nail Type
Tooth-And-Nail Syndrome	Dysplasia Of Nails With Hypodontia
Nail Dysplasia With Hypodontia	Witkop'S Syndrome
Hypodontia - Dysplasia Of Nails	Hypodontia-Dysplasia Of Nails Syndrome
Hypodontia-Nail Dysgenesis Syndrome	Hypodontia-Nail Dysgenesis

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

Catecholaminergic Polymorphic Ventricular Tachycardia 3	CPVT3
Cvpt3	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03789	DKK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W107409	Meridianin C		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DKK3	VGNC	VGNC:71804
Bos taurus	DKK3	VGNC	VGNC:28081
Felis catus	DKK3	VGNC	VGNC:61506
Canis familiaris	DKK3	VGNC	VGNC:39971
Rattus norvegicus	DKK3	RGD	RGD:621846
Mus musculus	DKK3	MGD	MGI:1354952
Others	DKK3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

关于 DKK3

功能概要

DKK3 基因产物(4)

DKK3 蛋白结构

重组 DKK3 蛋白

关联疾病

直系同源

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DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

关于 DKK3

功能概要

DKK3 基因产物(4)

DKK3 蛋白结构

重组 DKK3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z