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  2. DKK2 - dickkopf WNT signaling pathway inhibitor 2 Gene

DKK2 - dickkopf WNT signaling pathway inhibitor 2 Gene

中文名称:dickkopf WNT 信号通路抑制因子 2

种属: Homo sapiens

同用名: DKK-2

基因 ID: 27123 | 基因类型: protein coding

关于 DKK2

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:106,921,802-107,036,313 (from NCBI)

This gene has 4 transcripts (splice variants) and 93 orthologues. Broad expression in lung (RPKM 4.8), ovary (RPKM 3.0) and 14 other tissues.

功能概要

该基因编码的蛋白质是 dickkopf 家族的一员。分泌的蛋白质包含两个富含半胱氨酸的区域,并通过与 Wnt 信号通路的相互作用参与胚胎发育。它可以作为 Wnt/β-连环蛋白信号传导的激动剂或拮抗剂,具体取决于细胞环境和辅助因子 kremen 2 的存在。这种蛋白质的活性也通过与 Wnt 共受体 LDL- 结合来调节受体相关蛋白 6 (LRP6) 。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

DKK2 基因产物(1)

mRNA Protein Name
NM_014421.3 NP_055236.1 dickkopf-related protein 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21944579 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
11742004 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
12857724 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11742004 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DKK2 蛋白结构

Dickkopf_N

Dickkopf_N: Dickkopf N-terminal cysteine-rich region (77 - 129)

  • 0
  • 100
  • 200
  • 259 a.a.
蛋白主名 其他名称

dickkopf-related protein 2

dickkopf 2 homolog

DKK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DKK2 Q9UBU2 KRTAP10-6 Homo sapiens P60371 32296183
种属内
DKK2 Q9UBU2 KRTAP10-6 Homo sapiens P60371 32296183
种属内
DKK2 Q9UBU2 LRP6 Homo sapiens O75581 33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Witkop Syndrome

Tooth And Nail Syndrome

Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome

Tns

Ectodermal Dysplasia 3, Witkop Type

ECTD3

Ectodermal Dysplasia 3, Tooth/Nail Type

Tooth-And-Nail Syndrome

Dysplasia Of Nails With Hypodontia

Nail Dysplasia With Hypodontia

Witkop'S Syndrome

Hypodontia - Dysplasia Of Nails

Hypodontia-Dysplasia Of Nails Syndrome

Hypodontia-Nail Dysgenesis Syndrome

Hypodontia-Nail Dysgenesis

Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System

Axenfeld-Rieger Syndrome

Axenfeld Syndrome

Rieger Syndrome

Rieger Anomaly

Axenfeld Anomaly

Anomaly, Rieger'S

Hagedoom Syndrome

Rgs - Rieger Syndrome

Rieger'S Anomaly

Goniodysgenesis Hypodontia

Iridogoniodysgenesis With Somatic Anomalies

Ars

Axenfeld And Rieger Anomaly

Axra

Axrs

Rieger Eye Malformation Sequence

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome

Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus DKK2 VGNC VGNC:28080
Canis familiaris DKK2 VGNC VGNC:39970
Mus musculus DKK2 MGD MGI:1890663
Rattus norvegicus DKK2 RGD RGD:1308639
Macaca mulatta DKK2 VGNC VGNC:71802
Felis catus DKK2 VGNC VGNC:107326