2. Gene
  3. IL37 - interleukin 37 Gene

IL37 - interleukin 37 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：白细胞介素 37

种属: Homo sapiens

同用名: FIL1; FIL1Z; IL-1H; IL-23; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)

基因 ID: 27178 | 基因类型: protein coding

关于 IL37

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,911,165-112,918,882 (from NCBI)

This gene has 5 transcripts (splice variants), 177 orthologues, 7 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 8.8).

功能概要

该基因编码的蛋白质是白介素 1 细胞因子家族的成员。这种细胞因子可以结合并可能是白细胞介素 18 受体 (IL18R1/IL-1Rrp) 的配体。该细胞因子还与白细胞介素 18 结合蛋白 (IL18BP) 结合，后者是白细胞介素 18 (IL18) 的抑制性结合蛋白，随后与 IL18 受体 β 亚基形成复合物，从而抑制 IL18 的活性。该基因与其他八个白细胞介素 1 家族基因一起在 2 号染色体上形成细胞因子基因簇。已报道了编码不同亚型的五种选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL37 基因产物(5)

mRNA Protein Name
NM_014439.4 NP_055254.2 interleukin-37 isoform 1
NM_173202.2 NP_775294.1 interleukin-37 isoform 2
NM_173203.2 NP_775295.1 interleukin-37 isoform 3
NM_173204.2 NP_775296.1 interleukin-37 isoform 4
NM_173205.2 NP_775297.1 interleukin-37 isoform 5

IL37 蛋白结构

IL1

IL1: Interleukin-1 / 18 (98 - 197)

  • 0
  • 100
  • 200
  • 218 a.a.
蛋白主名 其他名称

interleukin-37

FIL1 zeta

重组 IL37 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70455 IL-37 Protein, Human Q9NZH6-1 (K53-D218) ≥95%
HY-P700128AF Animal-Free IL-37 Protein, Human (His) Q9NZH6 (K53-D218) ≥95%

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 31, Autosomal Recessive

IBD31

Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive

Inflammatory Bowel Disease 31

Inflammatory Bowel Disease 31, Autosomal Recessive
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Colitis
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Eumycotic Mycetoma

Eumycetoma

Maduromycosis

Mycetoma

Madura Foot

Maduromycosis, Mycotic

Mycotic Mycetoma

Mycetoma Of Foot

Eumycotic Maduromycosis

Mycetoma Due To Fungal Infection
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Dermatomycosis

Dermatomycoses
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06763 IL37 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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