2. Gene
  3. IL36A - interleukin 36 alpha Gene

IL36A - interleukin 36 alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 36 α

种属: Homo sapiens

同用名: FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)

基因 ID: 27179 | 基因类型: protein coding

关于 IL36A

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,005,459-113,011,072 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues and 7 paralogues. Restricted expression toward esophagus (RPKM 90.8).

功能概要

该基因编码的蛋白质是一种细胞因子，可以激活 NF-kappa-B 和 MAPK 信号通路产生炎症反应。编码的蛋白质主要在皮肤中发挥作用，并在牛皮癣中表现出增加的表达。此外，该基因表达的降低与肝细胞癌和结直肠癌患者的不良预后有关。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal Cancer patients. [provided by RefSeq, Nov 2015]

IL36A 基因产物(1)

mRNA Protein Name
NM_014440.3 NP_055255.1 interleukin-36 alpha

IL36A 蛋白结构

IL1

IL1: Interleukin-1 / 18 (51 - 152)

  • 0
  • 100
  • 158 a.a.
蛋白主名 其他名称

interleukin-36 alpha

FIL1 epsilon

重组 IL36A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70702 IL-36 alpha/IL-1F6 Protein, Human Q9UHA7 (K6-F158) ≥95%
HY-P700126AF Animal-Free IL-36 alpha/IL-1F6 Protein, Human (His) Q9UHA7 (K6-F158) ≥95%

关联疾病

疾病名称 别名
Psoriasis
Impetigo Herpetiformis
Pustulosis Of Palm And Sole

Psoriasis

Acropustulosis

Palmoplantar Pustulosis

Pustular Psoriasis Of The Palms And/Or Soles

Pustulosis Of Palms And Soles

Acrodermatitis Continua Of Hallopeau

Generalized Pustular Psoriasis
Psoriasis 14, Pustular

Generalized Pustular Psoriasis

Gpp

Ditra

Acrodermatitis Continua Of Hallopeau

Palmoplantar Pustulosis

PSORS14

Interleukin 36 Receptor Antagonist Deficiency

Psorp

Pustular Psoriasis 14

Deficiency Of Il-36r Antagonist

Acute Generalised Pustular Psoriasis

Deficiency Of The Interleukin-36 Receptor Antagonist

Generalized Pustular Psoriasis Of Von Zumbusch

Von Zumbusch Psoriasis

Deficiency Of Il-36ra

Psoriasis, Pustular, Generalized

Psoriasis, Pustular, Type 14

Pustulosis Of Palms And Soles

Acute Generalized Pustular Psoriasis

Palmoplantar Pustular Psoriasis

Pustulosis Palmaris Et Plantaris

Ppp - [Palmoplantar Pustulosis]

Pustular Psoriasis Of The Palms And Soles

Pustular Bacterid
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06759 IL36A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus IL36A VGNC VGNC:59221
Rattus norvegicus IL36A RGD RGD:1306869
Macaca mulatta IL36A VGNC VGNC:73602
Mus musculus IL36A MGD MGI:1859324
Others IL36A NCBI
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