2. Gene
  3. C5AR2 - complement C5a receptor 2 Gene

C5AR2 - complement C5a receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：补体 C5a 受体 2

种属: Homo sapiens

同用名: C5L2; GPF77; GPR77

基因 ID: 27202 | 基因类型: protein coding

关于 C5AR2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,332,175-47,347,329 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 8 paralogues. Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues.

功能概要

该基因编码参与先天免疫反应补体系统的 G 蛋白偶联受体 1 家族成员。与经典的 G 蛋白偶联受体不同，编码的蛋白质不与细胞内 G 蛋白结合。相反，它可以通过 β-抑制蛋白途径调节信号转导，并且可以替代地充当诱饵受体。该基因可能与冠状动脉疾病和败血症的发病机制有关。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 11 月]

This gene encodes a G-protein coupled receptor 1 family member involved in the Complement System of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

C5AR2 基因产物(3)

mRNA Protein Name
NM_001271749.2 NP_001258678.1 C5a anaphylatoxin chemotactic receptor 2
NM_001271750.2 NP_001258679.1 C5a anaphylatoxin chemotactic receptor 2
NM_018485.3 NP_060955.1 C5a anaphylatoxin chemotactic receptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12540846 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
16204243 GOA
involved in negative regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
16204243 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16204243 GOA
involved in regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
22496247 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
22496247 GOA
located in basal plasma membrane IDA
IDA: 通过直接分析推断
22960554 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

C5AR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (52 - 290)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
蛋白主名 其他名称

C5a anaphylatoxin chemotactic receptor 2

C5a anaphylatoxin chemotactic receptor C5L2

C5AR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
C5AR2 Q9P296 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
种属内
C5AR2 Q9P296 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
种属内
C5AR2 Q9P296 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Complement Component 5 Deficiency

C5 Deficiency

C5D
Complement Component 3 Deficiency

C3 Deficiency
Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

Atypical Hemolytic Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To

Ahus

AHUS1

Hemolytic-Uremic Syndrome

Ahus 1

Ahus, Susceptibility To, 1

Hemolytic Uremic Syndrome, Atypical

Non-Shiga-Like Toxin-Associated Hus

Non-Stx-Hus

Nonenteropathic Hus

Atypical Hus

Shiga Toxin-Associated Hemolytic Uremic Syndrome

D+ Hus

Ehec-Hus

Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

Hemolytic Uremic Syndrome With Diarrhea

Stec-Hus

Shiga-Like Toxin-Associated Hus

Stx-Hus

Typical Hus

Typical Hemolytic Uremic Syndrome

Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

Atypical Hus With Anti-Factor H Antibodies

Ahus With Anti-Factor H Antibodies

Ahus With Neutralizing Autoantibodies Against Factor H

Hemolytic Uremic Syndrome Atypical 1

Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

D Hus

Hemolytic-Uremic Syndrome Without Diarrhea

Hemolytic-Uremic Syndrome, Atypical, Type 1

Hemolytic Uremic Syndrome, Typical
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10639 C5aR2 agonist P32 Agonist 99.82% 否
HY-RS01751 C5AR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-P10639A C5aR2 agonist P32 acetate Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta C5AR2 VGNC VGNC:70690
Bos taurus C5AR2 VGNC VGNC:26642
Rattus norvegicus C5AR2 RGD RGD:1303027
Canis familiaris C5AR2 VGNC VGNC:38597
Mus musculus C5AR2 MGD MGI:2442013
Others C5AR2 NCBI
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