ANGPTL3 - angiopoietin like 3 Gene

中文名称：血管生成素 3

种属: Homo sapiens

同用名: ANL3; ANG-5; FHBL2; ANGPT5

基因 ID: 27329 | 基因类型: protein coding

关于 ANGPTL3

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,597,520-62,606,313 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues, 25 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 171.2).

功能概要

该基因编码在血管生成中起作用的分泌蛋白家族的成员。编码的蛋白质主要在肝脏中表达，进一步加工成包含 N 端卷曲螺旋结构域的链和 C 端纤维蛋白原链。 N 端链对脂质代谢很重要，而 C 端链可能参与血管生成。该基因的突变会导致 2 型家族性低β脂蛋白血症。[RefSeq 提供，2015 年 8 月]

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]

ANGPTL3 基因产物(1)

mRNA	Protein	Name
NM_014495.4	NP_055310.1	angiopoietin-related protein 3 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables growth factor activity	IDA IDA: 通过直接分析推断	11877390	GOA
enables integrin binding	IPI IPI: 通过物理相互作用推断	11877390	GOA
enables phospholipase inhibitor activity	IDA IDA: 通过直接分析推断	17110602	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in acylglycerol homeostasis	IDA IDA: 通过直接分析推断	17110602	GOA
involved in cell-matrix adhesion	IPI IPI: 通过物理相互作用推断	11877390	GOA
involved in cholesterol homeostasis	IDA IDA: 通过直接分析推断	17110602	GOA
involved in cholesterol metabolic process	IDA IDA: 通过直接分析推断	17110602	GOA
involved in fatty acid metabolic process	IDA IDA: 通过直接分析推断	12565906	GOA
involved in glycerol metabolic process	IDA IDA: 通过直接分析推断	12565906	GOA
involved in lipid homeostasis	IDA IDA: 通过直接分析推断	17110602	GOA
involved in lipid storage	IDA IDA: 通过直接分析推断	12565906	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: 通过直接分析推断	17110602	GOA
involved in negative regulation of phospholipase activity	IDA IDA: 通过直接分析推断	17110602	GOA
involved in phospholipid catabolic process	IDA IDA: 通过直接分析推断	17110602	GOA
involved in phospholipid homeostasis	IDA IDA: 通过直接分析推断	17110602	GOA
involved in phospholipid metabolic process	IDA IDA: 通过直接分析推断	17110602	GOA
involved in positive regulation of angiogenesis	IDA IDA: 通过直接分析推断	11877390	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	11877390	GOA
involved in positive regulation of lipid catabolic process	IDA IDA: 通过直接分析推断	12565906	GOA
involved in signal transduction	IDA IDA: 通过直接分析推断	11877390	GOA
acts upstream of or within triglyceride homeostasis	IGI IGI: 通过遗传相互作用推断	23150577	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	12565906	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	17110602	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANGPTL3 蛋白结构

Fibrinogen_C

0
100
200
300
400
460 a.a.

蛋白主名

其他名称

angiopoietin-related protein 3

angiopoietin 5

重组 ANGPTL3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7505	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His)	Q9Y5C1 (S17-P220)	≥95%
HY-P75580	ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His)	Q9Y5C1 (M1-E460)	≥95%
HY-P78059	ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9Y5C1 (S17-K219)	≥95%
HY-P78379	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi)	Q9Y5C1 (S17-K219)	≥95%

关联疾病

疾病名称

别名

Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2	FHBL2
Hypolipidemia, Familial, Combined	Combined Familial Hypolipidemia
Combined Hypobetalipoproteinemia Familial	Hypobetalipoproteinemia, Familial, Type 2

Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia	Familial Hypobetalipoproteinemia 1
Familial Hypobetalipoproteinemia	FHBL1
Hypobetalipoproteinemia, Familial	Fhbl
Acanthocytosis With Hypobetalipoproteinemia	Hypobetalipoproteinemias
Hypobetalipoproteinemia, Normotriglyceridemic	Hypo-Beta-Lipoproteinemia
Hypobetalipoprotéinemia, Familial	Normotriglyceridemic Hypobetalipoproteinemia
Hypobetalipoproteinemia, Familial, Type 1

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Hypolipoproteinemia

Hypolipoproteinaemia	Lipoprotein Deficiencies
Lipoprotein Disorder	Hypolipoproteinemias
Lipoprotein	Lipoprotein Deficiency
Hypolipidaemia	Lipoprotein Deficiency Disorder
High-Density Lipoid Deficiency	High-Density Lipoprotein Deficiency
Dyslipidaemia, Depressed Hdl Cholesterol

Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv	Carbohydrate-Inducible Hyperlipemia
Endogenous Hyperlipidaemia	Familial Hypertriglyceridemia
Fredrickson Type Iv Hyperlipoproteinemia	Fredrickson Type Iv Lipidaemia
Fredrickson Type Iv Lipidemia	Vldl Hyperlipoproteinemia
Hyperlipoproteinemia Type 4	Carbohydrate Inducible Hyperlipemia
Familial Type Iv Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iv

Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency	Familial Hyperchylomicronemia
Hyperlipoproteinemia Type I	Familial Hyperlipoproteinemia Type I
Hyperchylomicronemia	Burger-Grutz Syndrome
Endogenous Hypertriglyceridaemia	Familial Fat-Induced Hypertriglyceridemia
Lipd Deficiency	Lpl Deficiency
Lipase D Deficiency	Lipoprotein Lipase Deficiency, Familial
Familial Chylomicronemia Syndrome	Fredrickson Type I Hyperlipoproteinemia
Fredrickson Type I Lipaemia	Hypercholesterinaemic Xanthomatosis
Mixed Hyperglyceridemia	Lipoprotein Lipase Deficiency
Type I Hyperlipoproteinemia	Hyperlipoproteinemia Type Ia
Familial Hyperlipo-Proteinemia Type 1

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency	Familial Apoc2 Deficiency
C-Ii Anapolipoproteinemia	Hyperlipoproteinemia, Type 1b
Hyperlipoproteinemia, Type Ib	Hyperlipoproteinemia Type I

Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V	Hyperchylomicronemia, Late-Onset
Familial Type 5 Hyperlipoproteinemia	Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial
Hyperlipidemia, Type V	Hyperlipemia, Mixed
Hyperlipemia, Combined Fat And Carbohydrate-Induced	Familial Hyperlipoproteinemia Type V
Fredrickson Type V Lipaemia	Hyperlipoproteinemia Type 5
Hyperchylomicronemia Late Onset	Hyperlipemia Combined Fat And Carbohydrate-Induced
Hyperlipemia Mixed	Hyperlipidemia Type V
Mixed Hyperlipemia	Type V Hyperlipoproteinemia
Hyperlipoproteinemia 5	HLPP5
Hyperlipidemia, Familial Combined	Mixed Hyperlipidemia

Hypoalphalipoproteinemia, Primary, 1

Familial Hdl Deficiency	Fha
High Density Lipoprotein Deficiency	Familial Hypoalphalipoproteinemia
Hypoalphalipoproteinemia, Familial	Hdld
Fhd	Hdl Deficiency, Type 2
Primary Hypoalphalipoproteinemia 1	Hdl Cholesterol, Low Serum
Hdlc	Hdl Deficiency, Familial, 1
Hypoalphalipoproteinemia, Primary	Low Serum Hdl Cholesterol
Primary Hypoalphalipoproteinemia	FHA1
Hdld2	High Density Lipoprotein Deficiency 2
Hypoalphalipoproteinemias	Apolipoprotein A-I Deficiency

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia	Combined Hyperlipidemia, Familial
Mixed Hyperlipidaemia	FCHL3
Hyperlipidemia, Familial Combined	Familial Multiple Lipoprotein-Type Hyperlipidemia
Hyperbetalipoproteinemia With Prebetalipoproteinemia	Type Iib Hyperlipoproteinemia
Hyperlipidemia Familial Combined	Hyperlipoproteinemia Type Iib
Mixed Hyperlipemia	Hyperlipidaemia, Group C
Familial Hypercholesterolaemia With Hyperlipaemia	Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia
Hyperbetalipoproteinaemia With Prebetalipoproteinaemia	Hypercholesterolaemia With Endogenous Hyperglyceridaemia
Prebetalipoproteinemia Hyperbetalipoproteinaemia	Remnant Hyperlipoproteinemia

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Diabetes Mellitus

Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-153497	Vupanorsen	Inhibitor	92.29%	Phase 2
HY-153497A	Vupanorsen sodium	Inhibitor	92.29%	Phase 2

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ANGPTL3	VGNC	VGNC:99843
Canis familiaris	ANGPTL3	VGNC	VGNC:37859
Felis catus	ANGPTL3	VGNC	VGNC:67571
Bos taurus	ANGPTL3	VGNC	VGNC:25892
Rattus norvegicus	ANGPTL3	RGD	RGD:1564505
Mus musculus	ANGPTL3	MGD	MGI:1353627
Macaca fascicularis	ANGPTL3	NCBI	NCBI:102136264
Others	ANGPTL3	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ANGPTL3 - angiopoietin like 3 Gene

关于 ANGPTL3

功能概要

ANGPTL3 基因产物(1)

ANGPTL3 蛋白结构

重组 ANGPTL3 蛋白

关联疾病

直系同源

热门区域

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ANGPTL3 - angiopoietin like 3 Gene

关于 ANGPTL3

功能概要

ANGPTL3 基因产物(1)

ANGPTL3 蛋白结构

重组 ANGPTL3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z