2. Gene
  3. GNA12 - G protein subunit alpha 12 Gene

GNA12 - G protein subunit alpha 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：G 蛋白亚基α12

种属: Homo sapiens

同用名: RMP; gep; NNX3; HG1M1

基因 ID: 2768 | 基因类型: protein coding

关于 GNA12

Cytogenetic location: 7p22.3-p22.2 Genomic coordinates (GRCh38): 7:2,728,105-2,844,308 (from NCBI)

This gene has 8 transcripts (splice variants), 236 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 20.5), ovary (RPKM 16.5) and 25 other tissues.

功能概要

预测启用 D5 多巴胺受体结合活性； G 蛋白β/γ-亚基复合物结合活性；和 GTPase 活性。参与调节 TOR 信号和蛋白酶体泛素依赖性蛋白质分解代谢过程的调节。位于粘着斑。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable D5 Dopamine Receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

GNA12 基因产物(4)

mRNA Protein Name
NM_001282440.1 NP_001269369.1 guanine nucleotide-binding protein subunit alpha-12 isoform 2
NM_001282441.2 NP_001269370.1 guanine nucleotide-binding protein subunit alpha-12 isoform 3
NM_001293092.2 NP_001280021.1 guanine nucleotide-binding protein subunit alpha-12 isoform 4
NM_007353.3 NP_031379.2 guanine nucleotide-binding protein subunit alpha-12 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein activity IDA
IDA: 通过直接分析推断
8647866 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10026210 GOA
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
15525651 GOA
enables protein phosphatase regulator activity IDA
IDA: 通过直接分析推断
15525651 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of TOR signaling IMP
IMP: 通过突变表型推断
22609986 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
22609986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
15525651 GOA
located in neuron projection IDA
IDA: 通过直接分析推断
15525651 GOA
located in neuronal cell body IDA
IDA: 通过直接分析推断
15525651 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNA12 蛋白结构

G-alpha

G-alpha: G-protein alpha subunit (25 - 370)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
蛋白主名 其他名称

guanine nucleotide-binding protein subunit alpha-12

WUGSC:H_GS165O14.2

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05530 GNA12 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GNA12 RGD RGD:71018
Bos taurus GNA12 VGNC VGNC:29445
Macaca mulatta GNA12 VGNC VGNC:73086
Felis catus GNA12 VGNC VGNC:107756
Canis familiaris GNA12 VGNC VGNC:41297
Mus musculus GNA12 MGD MGI:95767
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