2. Gene
  3. GNG4 - G protein subunit gamma 4 Gene

GNG4 - G protein subunit gamma 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白亚基γ4

种属: Homo sapiens

同用名: HG3C

基因 ID: 2786 | 基因类型: protein coding

关于 GNG4

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,547,685-235,650,608 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 181 orthologues and 11 paralogues. Biased expression in brain (RPKM 11.8), ovary (RPKM 8.0) and 8 other tissues.

功能概要

预测启用 G 蛋白 β-亚基结合活性。参与细胞生长的负调节。位于细胞外外泌体。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GNG4 基因产物(3)

mRNA Protein Name
NM_001098721.2 NP_001092191.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
NM_001098722.2 NP_001092192.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
NM_004485.4 NP_004476.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23021213 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
15824735 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNG4 蛋白结构

G-gamma

G-gamma: GGL domain (12 - 75)

  • 0
  • 75 a.a.
蛋白主名 其他名称

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

guanine nucleotide binding protein (G protein), gamma 4

GNG4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GNG4 P50150 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05558 GNG4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GNG4 MGD MGI:102703
Rattus norvegicus GNG4 RGD RGD:620806
Macaca mulatta GNG4 VGNC VGNC:106372
Bos taurus GNG4 VGNC VGNC:29467
Canis familiaris GNG4 VGNC VGNC:51896
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