1. Gene
  2. GOT2 - glutamic-oxaloacetic transaminase 2 Gene

GOT2 - glutamic-oxaloacetic transaminase 2 Gene

中文名称:谷氨酸-草酰乙酸转氨酶 2

种属: Homo sapiens

同用名: KAT4; DEE82; KATIV; KYAT4; mitAAT

基因 ID: 2806 | 基因类型: protein coding

关于 GOT2

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,707,131-58,734,316 (from NCBI)

This gene has 7 transcripts (splice variants), 252 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 129.5), liver (RPKM 91.0) and 24 other tissues.

功能概要

谷氨酸草酰乙酸转氨酶是一种磷酸吡哆醛依赖性酶,分别以细胞质和内膜线粒体形式存在,分别为 GOT1 和 GOT2。 GOT 在氨基酸代谢以及尿素和三羧酸循环中发挥作用。这两种酶是同型二聚体并显示出密切的同源性。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2013 年 10 月]

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent Enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two Enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GOT2 基因产物(2)

mRNA Protein Name
NM_001286220.2 NP_001273149.1 aspartate aminotransferase, mitochondrial isoform 2 precursor
NM_002080.4 NP_002071.2 aspartate aminotransferase, mitochondrial isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: 通过直接分析推断
2182221 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aspartate catabolic process IDA
IDA: 通过直接分析推断
2567216 GOA
involved in fatty acid transport IEP
IEP: 通过表达模式推断
9537447 GOA
involved in response to ethanol IDA
IDA: 通过直接分析推断
9537447 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
9537447 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9537447 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GOT2 蛋白结构

Aminotran_1_2

Aminotran_1_2: Aminotransferase class I and II (58 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 430 a.a.
蛋白主名 其他名称

aspartate aminotransferase, mitochondrial

FABP-1

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 82

DEE82

Epileptic Encephalopathy, Early Infantile, 82

Eiee82

Got2 Deficiency

Developmental And Epileptic Encephalopathy, 82

Glutamate Oxaloacetate Transaminase, Mitochondrial, Deficiency Of

Early Infantile Epileptic Encephalopathy 82

Deficiency Of Mitochondrial Glutamate Oxaloacetate Transaminase

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.

Acute Git Vascular Insuffic.

Acute Intestinal Ischemia

Acute Intestinal Vascular Insufficiency

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile

Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia

Liver Benign Neoplasm

Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm

Median Arcuate Ligament Syndrome

Celiac Artery Compression Syndrome

Dunbar Syndrome

Mals

Harjola-Marable Syndrome

Marable'S Syndrome

Celiac Axis Syndrome

Neuroschistosomiasis
Fascioliasis

Fasciola Hepatica Infection

Infection By Fasciola

Sheep Liver Fluke Infection

Liver Flukes

Fasciola Infestation

Sheep Liver Fluke Disease

Liver Fluke Infestation

Liver Flukes Nos

Liver Fluke Infection

Liver Fluke Disease

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis

Enterocolitis Necrotizing

Enterocolitis, Necrotizing

Necrotizing Enterocolitis In Fetus Or Newborn

Perinatal Necrotising Enterocolitis

Pseudomembranous Enterocolitis In Newborn

Nec

Shrimp Allergy
Crustacean Allergy
Hepatocellular Adenoma

Adenoma Hepatocellular

Intestinal Schistosomiasis

Schistosomiasis Japonica

Schistosomiasis Mansoni

Katayama Fever

Schistosoma Japonicum Infection

Schistosoma Mansoni Infectious Disease

Schistosomiasis

Clonorchiasis

Oriental Liver Fluke Disease

Clonorchis Liver Infection

Clonorchiosis

Chinese Liver Fluke Disease

Hepatic Distomiasis Due To Clonorchis Sinensis

Infection Due To Clonorchis Sinensis

Hepatic Distomiasis

Hepatic Distomatosis

Chinese Liver Fluke Disorder

Oriental Liver Fluke Disorder

Clonorchis Infestation

Chinese Liver Fluke Infestation

Liver Fluke Disease Due To Clonorchis Sinensis

Oriental Liver Fluke Infestation

Hydrops Of Gallbladder

Gallbladder Hydrops

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3

MODY3

Mody, Type Iii

Mody Type 3

Mody, Type 3

Maturity-Onset Diabetes Of The Young 3

Mody-3

Diabetes Of The Young, Maturity-Onset, Type 3

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GOT2 VGNC VGNC:73112
Mus musculus GOT2 MGD MGI:95792
Felis catus GOT2 VGNC VGNC:97447
Rattus norvegicus GOT2 RGD RGD:2722
Bos taurus GOT2 VGNC VGNC:29503