FFAR1 - free fatty acid receptor 1 Gene

中文名称：游离脂肪酸受体 1

种属: Homo sapiens

同用名: FFA1R; GPR40; GPCR40

基因 ID: 2864 | 基因类型: protein coding

关于 FFAR1

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,347,902-35,353,864 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues and 15 paralogues.

功能概要

该基因编码 G 蛋白偶联受体 GP40 家族的一个成员，这些受体聚集在 19 号染色体上。编码的蛋白质是中长链游离脂肪酸的受体，可能参与胰岛素分泌的代谢调节。该基因的多态性可能与 2 型糖尿病有关。[RefSeq 提供，2009 年 4 月]

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of Insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]

FFAR1 基因产物(1)

mRNA	Protein	Name
NM_005303.3	NP_005294.1	free fatty acid receptor 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables bioactive lipid receptor activity	IDA IDA: 通过直接分析推断	24130766	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of interleukin-1 beta production	IMP IMP: 通过突变表型推断	23809162	GOA
involved in positive regulation of calcium ion transport	IDA IDA: 通过直接分析推断	24130766	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	24742677	GOA
involved in response to fatty acid	IDA IDA: 通过直接分析推断	24130766	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	24130766	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FFAR1 蛋白结构

7tm_1

0
100
200
300 a.a.

蛋白主名

其他名称

free fatty acid receptor 1

G-protein coupled receptor 40

关联疾病

疾病名称

别名

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101906	DC260126		99.74%	否
HY-111763	GPR40/FFAR1 modulator 1	Agonist	98.28%	否
HY-147351	GPR40 agonist 6	Agonist	99.64%	否
HY-148418	TUG-499	Agonist	99.78%	否
HY-148235	TP-051	Agonist	/	否
HY-148247	BI-2081	Agonist	/	否
HY-164870	FFAR1/FFAR4 agonist-1	Agonist	/	否
HY-RS04874	FFAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FFAR1	VGNC	VGNC:40830
Bos taurus	FFAR1	VGNC	VGNC:28961
Felis catus	FFAR1	VGNC	VGNC:67428
Rattus norvegicus	FFAR1	RGD	RGD:628613
Macaca mulatta	FFAR1	VGNC	VGNC:72705
Mus musculus	FFAR1	MGD	MGI:2684079

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FFAR1 - free fatty acid receptor 1 Gene

关于 FFAR1

功能概要

FFAR1 基因产物(1)

FFAR1 蛋白结构

关联疾病

直系同源

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FFAR1 - free fatty acid receptor 1 Gene

关于 FFAR1

功能概要

FFAR1 基因产物(1)

FFAR1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z