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  2. Bace2 - beta-secretase 2 Gene

Bace2 - beta-secretase 2 Gene

中文名称:β-分泌酶 2

种属: Rattus norvegicus

基因 ID: 288227 | 基因类型: protein coding

关于 Bace2

Primary_assembly 11: 36,707,458-36,789,546 forward strand.mRatBN7.2:CM026984.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 61.5), Lung (RPKM 44.1) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动天冬氨酸型内肽酶活性。参与星形胶质细胞活化。位于致密的核心颗粒中。该基因的人类直系同源物与阿尔茨海默病有关。与人类 BACE2(β-分泌酶 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (Beta-secretase 2). [provided by Alliance of Genome Resources, Apr 2022]

Bace2 基因产物(1)

mRNA Protein Name
NM_001002802.2 NP_001002802.1 beta-secretase 2 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte activation IEP
IEP: 通过表达模式推断
21073551 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dense core granule IDA
IDA: 通过直接分析推断
19117266 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Bace2 蛋白结构

beta_secretase_like

beta_secretase_like: cd05473 (84 - 445)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
蛋白主名 其他名称

beta-secretase 2

beta-site APP-cleaving enzyme 2

beta-site amyloid precursor protein cleaving enzyme 2

memapsin-1

membrane-associated aspartic protease 1

theta-secretase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bace2 NCBI NCBI:25825
Mus musculus Bace2 NCBI NCBI:56175