1. Gene
  2. Ifnar1 - interferon alpha and beta receptor subunit 1 Gene

Ifnar1 - interferon alpha and beta receptor subunit 1 Gene

中文名称:干扰素 α 和 β 受体亚基 1

种属: Rattus norvegicus

基因 ID: 288264 | 基因类型: protein coding

关于 Ifnar1

Primary_assembly 11: 30,725,790-30,749,979 forward strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 19 phenotypes. Biased expression in Lung (RPKM 331.9), Spleen (RPKM 237.2) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动 I 型干扰素结合活性和 I 型干扰素受体活性。参与细胞因子介导的信号通路。预计是质膜的组成部分。该基因的人类直系同源物与丙型肝炎有关。与人类 IFNAR1(干扰素 α 和 β 受体亚基 1)直系同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable type I interferon binding activity and type I interferon receptor activity. Involved in cytokine-mediated signaling pathway. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnar1 基因产物(2)

mRNA Protein Name
NM_001271316.1 NP_001258245.1 interferon alpha/beta receptor 1 isoform 2
NM_001105893.1 NP_001099363.2 interferon alpha/beta receptor 1 isoform 1 precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
27999109 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ifnar1 蛋白结构

FN3

FN3: cl21522 (17 - 113)

Interfer-bind

Interfer-bind: pfam09294 (125 - 222)

FN3

FN3: cl21522 (221 - 316)

FN3

FN3: cl21522 (328 - 424)

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  • 593 a.a.
蛋白主名 其他名称

interferon alpha/beta receptor 1

interferon (alpha and beta) receptor 1

interferon (alpha, beta and omega) receptor 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ifnar1 NCBI NCBI:3454
Macaca fascicularis Ifnar1 NCBI NCBI:101926190
Mus musculus Ifnar1 NCBI NCBI:15975
Macaca mulatta Ifnar1 NCBI NCBI:699604