2. Gene
  3. NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 Gene

NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：N-末端 Xaa-Pro-Lys N-甲基转移酶 1

种属: Homo sapiens

同用名: NRMT; NRMT1; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A

基因 ID: 28989 | 基因类型: protein coding

关于 NTMT1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,608,872-129,636,135 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.4), adrenal (RPKM 9.8) and 25 other tissues.

功能概要

METTL11A 基因编码 RAN (MIM 601179) 鸟嘌呤核苷酸交换因子调节染色体浓缩 1 (RCC1; MIM 179710) 的 N 端甲基转移酶。 METTL11A 酶 alpha-N- 甲基化其他蛋白质靶标，例如 SET (MIM 600960) 和 RB (MIM 180200) 。[OMIM 提供，2010 年 11 月]

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A Enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

NTMT1 基因产物(9)

mRNA Protein Name
NM_001286796.2 NP_001273725.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286797.2 NP_001273726.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286798.2 NP_001273727.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286799.2 NP_001273728.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286800.2 NP_001273729.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286801.2 NP_001273730.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286802.2 NP_001273731.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_001286803.2 NP_001273732.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_014064.4 NP_054783.2 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-terminal protein N-methyltransferase activity IDA
IDA: 通过直接分析推断
26543159 GOA
enables histone methyltransferase activity IDA
IDA: 通过直接分析推断
26543159 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20668449 GOA
enables protein methyltransferase activity IDA
IDA: 通过直接分析推断
20481588 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-terminal peptidyl-glycine methylation IDA
IDA: 通过直接分析推断
26543159 GOA
involved in N-terminal peptidyl-proline dimethylation IDA
IDA: 通过直接分析推断
20481588 GOA
involved in N-terminal peptidyl-serine dimethylation IDA
IDA: 通过直接分析推断
20668449 GOA
involved in N-terminal peptidyl-serine trimethylation IDA
IDA: 通过直接分析推断
20668449 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
20668449 GOA
involved in spindle organization IMP
IMP: 通过突变表型推断
20668449 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
20668449 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NTMT1 蛋白结构

Methyltransf_PK

Methyltransf_PK: AdoMet dependent proline di-methyltransferase (8 - 223)

  • 0
  • 100
  • 200
  • 223 a.a.
蛋白主名 其他名称

N-terminal Xaa-Pro-Lys N-methyltransferase 1

N-terminal RCC1 methyltransferase

重组 NTMT1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77447 METTL11A Protein, Human Q9BV86-1 (T2-R223) ≥95%
HY-P77448 METTL11A Protein, Human (GST) Q9BV86-1 (T2-R223) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10407 BM30 Inhibitor / 否
HY-RS09620 NTMT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NTMT1 VGNC VGNC:44006
Bos taurus NTMT1 VGNC VGNC:32303
Felis catus NTMT1 VGNC VGNC:102959
Macaca mulatta NTMT1 VGNC VGNC:75451
Mus musculus NTMT1 MGD MGI:1913867
Rattus norvegicus NTMT1 RGD RGD:1306582
Others NTMT1 NCBI
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