2. Gene
  3. GRIK4 - glutamate ionotropic receptor kainate type subunit 4 Gene

GRIK4 - glutamate ionotropic receptor kainate type subunit 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氨酸离子型受体红藻氨酸亚基 4

种属: Homo sapiens

同用名: KA1; EAA1; GRIK; GluK4; GluK4-2

基因 ID: 2900 | 基因类型: protein coding

关于 GRIK4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:120,511,748-120,988,906 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues and 17 paralogues. Biased expression in brain (RPKM 2.8), ovary (RPKM 0.9) and 4 other tissues.

功能概要

该基因编码一种属于谷氨酸门控离子通道家族的蛋白质。谷氨酸通过激活配体门控离子通道和 G 蛋白偶联膜受体发挥中枢神经系统中主要兴奋性神经递质的作用。由该基因编码的蛋白质与相关基因家族成员编码的亚基形成功能性异聚红藻氨酸偏好离子通道。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GRIK4 基因产物(3)

mRNA Protein Name
NM_001282470.3 NP_001269399.1 glutamate receptor ionotropic, kainate 4 isoform 1 precursor
NM_001282473.3 NP_001269402.1 glutamate receptor ionotropic, kainate 4 isoform 2 precursor
NM_014619.5 NP_055434.2 glutamate receptor ionotropic, kainate 4 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: 通过直接分析推断
20026616 GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: 通过突变表型推断
20026616 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRIK4 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (45 - 380)

Lig_chan-Glu_bd

Lig_chan-Glu_bd: Ligated ion channel L-glutamate- and glycine-binding site (427 - 490)

Lig_chan

Lig_chan: Ligand-gated ion channel (547 - 816)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
蛋白主名 其他名称

glutamate receptor ionotropic, kainate 4

GluK4(alt_5'UTR)

GRIK4 抗体

目录号 产品名 应用 反应物种
HY-P82134 KA1 Antibody (YA1879) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation
Depersonalization Disorder

Neurotic Derealization

Depersonalization

Depersonalization/Derealization Disorder

Depersonalisation-Derealization Syndrome

Depersonalisation Disorder

Depersonalisation Neurosis

Depersonalisation Syndrome

Feeling Of Unreality

Feels Own Self Is Unreal

Neurotic State With Depersonalisation

Neurotic State With Depersonalization Episode
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

MLC2A

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05801 GRIK4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GRIK4 MGD MGI:95817
Felis catus GRIK4 VGNC VGNC:103032
Macaca mulatta GRIK4 VGNC VGNC:73279
Rattus norvegicus GRIK4 RGD RGD:2734
Canis familiaris GRIK4 VGNC VGNC:41489
Bos taurus GRIK4 VGNC VGNC:54882
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