1. Gene
  2. WDR91 - WD repeat domain 91 Gene

WDR91 - WD repeat domain 91 Gene

中文名称:WD 重复域 91

种属: Homo sapiens

同用名: SORF1; SORF-1; HSPC049

基因 ID: 29062 | 基因类型: protein coding

关于 WDR91

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,183,839-135,211,526 (from NCBI)

This gene has 21 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues.

功能概要

启用磷脂酰肌醇 3-激酶调节剂活性。参与早期内体到晚期内体的运输;调节细胞蛋白质分解代谢过程;和调节磷脂酰肌醇 3-激酶活性。位于胞质溶胶中;早期内体膜;和晚期内体膜。是核内体膜的外在成分。 [由基因组资源联盟提供,2022 年 4 月]

Enables phosphatidylinositol 3-kinase regulator activity. Involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Located in cytosol; early endosome membrane; and late endosome membrane. Is extrinsic component of endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

WDR91 基因产物(4)

mRNA Protein Name
NM_001362736.2 NP_001349665.1 WD repeat-containing protein 91 isoform 2
NM_001362737.2 NP_001349666.1 WD repeat-containing protein 91 isoform 1
NM_001362738.2 NP_001349667.1 WD repeat-containing protein 91 isoform 4
NM_014149.4 NP_054868.3 WD repeat-containing protein 91 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol 3-kinase inhibitor activity IMP
IMP: 通过突变表型推断
26783301 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in early endosome to late endosome transport IMP
IMP: 通过突变表型推断
26783301 GOA
involved in regulation of protein catabolic process IMP
IMP: 通过突变表型推断
27126989 GOA
NOT involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
28404643 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
26783301 GOA
located in early endosome membrane IDA
IDA: 通过直接分析推断
26783301 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
26783301 GOA
located in late endosome membrane IDA
IDA: 通过直接分析推断
26783301 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WDR91 蛋白结构

WD40

WD40: WD domain, G-beta repeat (404 - 436)

WD40

WD40: WD domain, G-beta repeat (564 - 590)

WD40

WD40: WD domain, G-beta repeat (595 - 632)

WD40

WD40: WD domain, G-beta repeat (706 - 739)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
蛋白主名 其他名称

WD repeat-containing protein 91

WDR91 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WDR91 A4D1P6 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
WDR91 A4D1P6 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
WDR91 A4D1P6 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
WDR91 A4D1P6 WDR81 Homo sapiens Q562E7
Anti Tag CoIP
26783301
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Laryngotracheitis
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

Dysequilibrium Syndrome

CAMRQ1

Des

Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1

Cerebellar Hypoplasia, Vldlr-Associated

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome

Uner Tan Syndrome

Vldlr Cerebellar Hypoplasia

Vldlrch

Vldlr-Associated Cerebellar Hypoplasia

Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive

Camrq

Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1

Cerebellar Disorder, Nonprogressive, With Intellectual Disability

Cerebellar Hypoplasia, Vldlr Associated

Autosomal Recessive Cerebellar Ataxia With Mental Retardation

Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification

Cerebellar Disorder, Nonprogressive, With Mental Retardation

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion

Chmrq1

Des-Vldlr

Dysequilibrium Syndrome-Vldlr

Vldlr-Ch

Camrq Syndrome

Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome

Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome

Uts

Cerebellar Hypoplasia Vldlr-Associated

Dialysis Disequilibrium Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta WDR91 VGNC VGNC:79464
Mus musculus WDR91 MGD MGI:2141558
Rattus norvegicus WDR91 RGD RGD:1306697
Canis familiaris WDR91 VGNC VGNC:48398
Bos taurus WDR91 VGNC VGNC:36927
Felis catus WDR91 VGNC VGNC:67063