Adora1 - adenosine A1 receptor Gene

中文名称：腺苷 A1 受体

种属: Rattus norvegicus

基因 ID: 29290 | 基因类型: protein coding

关于 Adora1

Primary_assembly 13: 45,658,872-45,695,801 reverse strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 274 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Brain (RPKM 184.), Spleen (RPKM 61.9) and 8 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 G 蛋白偶联腺苷受体活性； G蛋白β/γ-亚基复合物结合活性；和异源三聚体 G 蛋白结合活性。参与多个过程，包括脂质稳态；化学突触传递的调节；和分泌调节。位于多个细胞成分中，包括轴突；基底外侧质膜；和突触膜。在 Held 的花萼中活跃。是突触后膜的组成部分和突触前膜的组成部分。用于研究脑梗塞；高血压;肺部疾病;和阻塞性睡眠呼吸暂停。该基因的人类直系同源物与哮喘有关。与人类 ADORA1（腺苷 A1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including G protein-coupled Adenosine Receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including lipid homeostasis; modulation of chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axon; basolateral plasma membrane; and synaptic membrane. Is active in calyx of Held. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora1 基因产物(1)

mRNA	Protein	Name
NM_017155.3	NP_058851.2	adenosine receptor A1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled adenosine receptor activity	IDA IDA: 通过直接分析推断	9261808	RGD
enables G protein-coupled receptor binding	IPI IPI: 通过物理相互作用推断	11390975	RGD
enables G-protein beta/gamma-subunit complex binding	IDA IDA: 通过直接分析推断	12764156	RGD
enables heat shock protein binding	IPI IPI: 通过物理相互作用推断	10866672	RGD
enables heterotrimeric G-protein binding	IDA IDA: 通过直接分析推断	12764156	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	11390975	RGD
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	11390975	RGD
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	16481441	RGD
enables purine nucleoside binding	IPI IPI: 通过物理相互作用推断	11906959	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	12764156	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	16286581	RGD
involved in cognition	IMP IMP: 通过突变表型推断	19307960	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: 通过突变表型推断	20065990	RGD
involved in excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	19942300	RGD
involved in fatty acid homeostasis	IDA IDA: 通过直接分析推断	15220221	RGD
involved in lipid catabolic process	IMP IMP: 通过突变表型推断	19093734	RGD
involved in negative regulation of acute inflammatory response	IDA IDA: 通过直接分析推断	2167912	RGD
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	12578815	RGD
involved in negative regulation of blood pressure	IMP IMP: 通过突变表型推断	16690710	RGD
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	12021208	RGD
involved in negative regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: 通过突变表型推断	19491711	RGD
involved in negative regulation of circadian sleep/wake cycle, sleep	IDA IDA: 通过直接分析推断	16109808	RGD
involved in negative regulation of glutamate secretion	IDA IDA: 通过直接分析推断	16481441	RGD
involved in negative regulation of hormone secretion	IMP IMP: 通过突变表型推断	15044554	RGD
involved in negative regulation of lipid catabolic process	IDA IDA: 通过直接分析推断	15220221	RGD
involved in negative regulation of long-term synaptic potentiation	IMP IMP: 通过突变表型推断	14596853	RGD
involved in negative regulation of neurotrophin production	IMP IMP: 通过突变表型推断	19524026	RGD
NOT involved in negative regulation of synaptic transmission, GABAergic	IDA IDA: 通过直接分析推断	12626609	RGD
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: 通过突变表型推断	12626609	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IDA IDA: 通过直接分析推断	16481441	RGD
involved in negative regulation of systemic arterial blood pressure	IDA IDA: 通过直接分析推断	9597368	RGD
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	12764156	RGD
involved in positive regulation of blood pressure	IDA IDA: 通过直接分析推断	12234813	RGD
involved in positive regulation of dephosphorylation	IDA IDA: 通过直接分析推断	12234781	RGD
involved in positive regulation of epidermal growth factor-activated receptor activity	IMP IMP: 通过突变表型推断	19574994	RGD
involved in positive regulation of lipid catabolic process	IDA IDA: 通过直接分析推断	9597368	RGD
involved in positive regulation of nucleoside transport	IDA IDA: 通过直接分析推断	15024061	RGD
involved in positive regulation of peptide secretion	IMP IMP: 通过突变表型推断	16286581	RGD
involved in positive regulation of potassium ion transport	IDA IDA: 通过直接分析推断	9261808	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: 通过突变表型推断	8998253	RGD
involved in protein targeting to membrane	IMP IMP: 通过突变表型推断	19879903	RGD
involved in regulation of cardiac muscle cell contraction	IDA IDA: 通过直接分析推断	19525381	RGD
involved in regulation of cardiac muscle contraction	IMP IMP: 通过突变表型推断	20334814	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: 通过实验结果推断	12963795	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	12963795	RGD
involved in regulation of respiratory gaseous exchange by nervous system process	IMP IMP: 通过突变表型推断	16352472	RGD
involved in response to hypoxia	IMP IMP: 通过突变表型推断	16690710	RGD
involved in temperature homeostasis	IMP IMP: 通过突变表型推断	16352472	RGD
involved in triglyceride homeostasis	IDA IDA: 通过直接分析推断	15220221	RGD
involved in vasodilation	IDA IDA: 通过直接分析推断	12100087	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in asymmetric synapse	IDA IDA: 通过直接分析推断	16481441	RGD
located in axolemma	IDA IDA: 通过直接分析推断	16481441	RGD
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	15024061	RGD
is active in calyx of Held	EXP EXP: 通过实验结果推断	12963795	RGD
is active in calyx of Held	IDA IDA: 通过直接分析推断	12963795	RGD
located in cell body	IDA IDA: 通过直接分析推断	12417330	RGD
located in dendrite	IDA IDA: 通过直接分析推断	12417330	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	15044554	RGD
is active in postsynaptic membrane	IDA IDA: 通过直接分析推断	16952160	RGD
located in postsynaptic membrane	IDA IDA: 通过直接分析推断	16481441	RGD
located in presynaptic active zone	IDA IDA: 通过直接分析推断	16481441	RGD
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	16952160	RGD
located in presynaptic membrane	IDA IDA: 通过直接分析推断	16481441	RGD
located in terminal bouton	IDA IDA: 通过直接分析推断	16952160	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Adora1 蛋白结构

7tmA_Adenosine_R_A1

0
100
200
300
326 a.a.

蛋白主名

其他名称

adenosine receptor A1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00391	ADORA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00392	Adora1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00393	Adora1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Adora1	NCBI	NCBI:134

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Adora1 - adenosine A1 receptor Gene

关于 Adora1

功能概要

Adora1 基因产物(1)

Adora1 蛋白结构

直系同源

热门区域

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Adora1 - adenosine A1 receptor Gene

关于 Adora1

功能概要

Adora1 基因产物(1)

Adora1 蛋白结构

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z