2. Gene
  3. Adora2b - adenosine A2B receptor Gene

Adora2b - adenosine A2B receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：腺苷 A2B受体

种属: Rattus norvegicus

基因 ID: 29316 | 基因类型: protein coding

关于 Adora2b

Primary_assembly 10: 46,940,384-46,956,772 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 3 paralogues and is associated with 9 phenotypes. Biased expression in Lung (RPKM 18.9), Brain (RPKM 17.7) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联受体活性。参与多个过程，包括胶原生物合成过程的负调控；正向调节 cAMP 介导的信号；白细胞介素 6 生成的正向调节。位于细胞表面和质膜。与人类 ADORA2B（腺苷 A2b 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of collagen biosynthetic process; positive regulation of cAMP-mediated signaling; and positive regulation of interleukin-6 production. Located in cell surface and plasma membrane. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2b 基因产物(1)

mRNA Protein Name
NM_017161.2 NP_058857.2 adenosine receptor A2b
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11230362 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
9535419 RGD
involved in positive regulation of cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
8012696 RGD
involved in positive regulation of catecholamine secretion IMP
IMP: 通过突变表型推断
18823369 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12021208 RGD
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
11882603 RGD
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
11882603 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
26385692 RGD
involved in positive regulation of norepinephrine secretion IMP
IMP: 通过突变表型推断
15223300 RGD
involved in positive regulation of steroid biosynthetic process IMP
IMP: 通过突变表型推断
18582595 RGD
involved in regulation of glucose metabolic process IMP
IMP: 通过突变表型推断
26385692 RGD
involved in response to angiotensin IMP
IMP: 通过突变表型推断
26385692 RGD
involved in vasodilation IDA
IDA: 通过直接分析推断
10666062 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
12021208 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Adora2b 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (7 - 300)

7tm_GPCRs

7tm_GPCRs: cd14964 (9 - 33)

7tm_GPCRs

7tm_GPCRs: cd14964 (42 - 64)

7tm_GPCRs

7tm_GPCRs: cd14964 (78 - 100)

7tm_GPCRs

7tm_GPCRs: cd14964 (123 - 139)

7tm_GPCRs

7tm_GPCRs: cd14964 (179 - 202)

7tm_GPCRs

7tm_GPCRs: cd14964 (232 - 254)

7tm_GPCRs

7tm_GPCRs: cd14964 (268 - 293)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

adenosine receptor A2b

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adora2b NCBI NCBI:136
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