2. Gene
  3. Prkce - protein kinase C, epsilon Gene

Prkce - protein kinase C, epsilon Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C，ε

种属: Rattus norvegicus

同用名: Pkce

基因 ID: 29340 | 基因类型: protein coding

关于 Prkce

Primary_assembly 6: 7,965,048-8,451,719 reverse strand.mRatBN7.2:CM026979.1

This gene has 3 transcripts (splice variants), 312 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 183.2), Heart (RPKM 82.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 SH3 域绑定活动；蛋白激酶 C 活性；和蛋白激酶结合活性。参与多个过程，包括细胞对血小板衍生生长因子刺激的反应；线粒体钙离子浓度的负调节；和线粒体膜电位的负调节。位于高尔基体膜； T 小管；和胞质溶胶。在谷氨酸能突触中活跃；神经肌肉接头;和突触前细胞质。用于研究高血压。 2 型糖尿病的生物标志物。与人 PRKCE（蛋白激酶 C epsilon）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including SH3 domain binding activity; protein kinase C activity; and protein kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Located in Golgi membrane; T-tubule; and cytosol. Is active in glutamatergic synapse; neuromuscular junction; and presynaptic cytosol. Used to study hypertension. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Prkce 基因产物(1)

mRNA Protein Name
NM_017171.2 NP_058867.2 protein kinase C epsilon type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
17084383 RGD
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IMP
IMP: 通过突变表型推断
22619279 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9360998 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17084383 RGD
enables protein serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
15652511 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
20383739 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to platelet-derived growth factor stimulus IMP
IMP: 通过突变表型推断
22619279 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11562372 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
20383739 RGD
involved in negative regulation of mitochondrial calcium ion concentration IMP
IMP: 通过突变表型推断
20383739 RGD
involved in negative regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
20383739 RGD
involved in negative regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
20383739 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
26625935 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26625935 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
9360998 RGD
located in T-tubule IDA
IDA: 通过直接分析推断
19525381 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
8481800 RGD
is active in neuromuscular junction EXP
EXP: 通过实验结果推断
26625935 RGD
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
26625935 RGD
is active in presynaptic cytosol IDA
IDA: 通过直接分析推断
8481800 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkce 蛋白结构

C2_PKC_epsilon

C2_PKC_epsilon: cd04014 (2 - 134)

C1_nPKC_epsilon-like_rpt1

C1_nPKC_epsilon-like_rpt1: cd20835 (160 - 223)

C1_nPKC_epsilon-like_rpt2

C1_nPKC_epsilon-like_rpt2: cd20838 (240 - 294)

STKc_nPKC_epsilon

STKc_nPKC_epsilon: cd05591 (411 - 731)

  • 0
  • 200
  • 400
  • 600
  • 737 a.a.
蛋白主名 其他名称

protein kinase C epsilon type

nPKC-epsilon

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1803 Protein Kinase C Peptide Substrate / 否
HY-RS11125 PRKCE Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11126 Prkce Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11127 Prkce Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkce NCBI NCBI:5581
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