PRKCE - protein kinase C epsilon Gene

中文名称：蛋白激酶 C epsilon

种属: Homo sapiens

同用名: PKCE; nPKC-epsilon

基因 ID: 5581 | 基因类型: protein coding

关于 PRKCE

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:45,651,279-46,187,990 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 9 paralogues. Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues.

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯 (一类肿瘤促进剂) 的主要受体。 PKC 家族的每个成员都有特定的表达谱，并被认为在细胞中发挥着独特的作用。该基因编码的蛋白质是 PKC 家族成员之一。这种激酶已被证明参与许多不同的细胞功能，例如神经元通道激活、细胞凋亡、心肌缺血保护、热休克反应以及胰岛素胞吐作用。小鼠基因敲除研究表明，这种激酶对激活的巨噬细胞中脂多糖 (LPS) 介导的信号传导很重要，也可能在控制焦虑样行为中发挥作用。[RefSeq 提供，2008 年 7 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, Apoptosis, cardioprotection from ischemia, heat shock response, as well as Insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

PRKCE 基因产物(23)

mRNA	Protein	Name
XM_011532981.4	XP_011531283.1	protein kinase C epsilon type isoform X4
XM_011532983.3	XP_011531285.1	protein kinase C epsilon type isoform X9
XM_047445096.1	XP_047301052.1	protein kinase C epsilon type isoform X2
XR_007078551.1
XM_047445098.1	XP_047301054.1	protein kinase C epsilon type isoform X2
XM_017004488.3	XP_016859977.1	protein kinase C epsilon type isoform X3
XM_047445097.1	XP_047301053.1	protein kinase C epsilon type isoform X2
XR_939695.3
XM_047445094.1	XP_047301050.1	protein kinase C epsilon type isoform X2
XM_047445095.1	XP_047301051.1	protein kinase C epsilon type isoform X2
XM_006712050.4	XP_006712113.1	protein kinase C epsilon type isoform X8
XM_047445099.1	XP_047301055.1	protein kinase C epsilon type isoform X3
XM_011532975.4	XP_011531277.1	protein kinase C epsilon type isoform X2
XM_011532980.4	XP_011531282.1	protein kinase C epsilon type isoform X4
XM_005264428.2	XP_005264485.1	protein kinase C epsilon type isoform X1
XM_017004490.3	XP_016859979.1	protein kinase C epsilon type isoform X4
XM_011532982.3	XP_011531284.1	protein kinase C epsilon type isoform X5
XM_011532971.4	XP_011531273.1	protein kinase C epsilon type isoform X2
XM_005264431.5	XP_005264488.1	protein kinase C epsilon type isoform X6
NM_005400.3	NP_005391.1	protein kinase C epsilon type
XM_011532978.3	XP_011531280.1	protein kinase C epsilon type isoform X3
XM_017004492.3	XP_016859981.1	protein kinase C epsilon type isoform X7
XM_047445100.1	XP_047301056.1	protein kinase C epsilon type isoform X10

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA IDA: 通过直接分析推断	18556656	GOA
enables enzyme activator activity	IMP IMP: 通过突变表型推断	18556656	GOA
enables enzyme binding	IDA IDA: 通过直接分析推断	18556656	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	15632189	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16810323	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	19542546	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	15695813	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	15695813	GOA
involved in positive regulation of cellular glucuronidation	IMP IMP: 通过突变表型推断	18556656	GOA
involved in positive regulation of cytokinesis	IMP IMP: 通过突变表型推断	18604201	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	17603037	GOA
involved in positive regulation of wound healing	IMP IMP: 通过突变表型推断	17603037	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	34593629	GOA
acts upstream of toxin catabolic process	IDA IDA: 通过直接分析推断	18556656	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15632189	GOA
located in cytosol	IDA IDA: 通过直接分析推断	17603037	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	18556656	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15632189	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCE 蛋白结构

C1_1

Pkinase

Pkinase_C

0
200
400
600
737 a.a.

蛋白主名

其他名称

protein kinase C epsilon type

重组 PRKCE 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71208	PKCE Protein, Human (His)	Q02156 (Q580-P737)	≥95%

关联疾病

疾病名称

别名

Ischemia

Acute Coronary Syndrome

Alcoholic Neuropathy

Alcoholic Polyneuropathy	Alcohol-Related Polyneuropathy
Alcohol-Induced Polyneuropathy	Alcoholic Peripheral Neuropathy

Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay	Aarskog-Ose-Pande Syndrome
Lipodystrophy, Partial, With Rieger Anomaly And Short Stature	Lipodystrophy-Rieger Anomaly-Diabetes Syndrome
Rieger Anomaly-Partial Lipodystrophy Syndrome	Partial Lipodystrophy With Rieger Anomaly And Short Stature
Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay	Growth Retardation-Rieger Anomaly
Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay	SHORTS

Rift Valley Fever

Rfv - [Rift Valley Fever]

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2	SRTD2
Atd2	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 2

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11125	PRKCE Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11126	Prkce Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11127	Prkce Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PRKCE	RGD	RGD:61925
Bos taurus	PRKCE	VGNC	VGNC:33330
Felis catus	PRKCE	VGNC	VGNC:69060
Canis familiaris	PRKCE	VGNC	VGNC:44980
Macaca mulatta	PRKCE	VGNC	VGNC:76412
Mus musculus	PRKCE	MGD	MGI:97599
Others	PRKCE	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRKCE - protein kinase C epsilon Gene

关于 PRKCE

功能概要

PRKCE 基因产物(23)

PRKCE 蛋白结构

重组 PRKCE 蛋白

关联疾病

直系同源

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PRKCE - protein kinase C epsilon Gene

关于 PRKCE

功能概要

PRKCE 基因产物(23)

PRKCE 蛋白结构

重组 PRKCE 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z