2. Gene
  3. Acvr1b - activin A receptor type 1B Gene

Acvr1b - activin A receptor type 1B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：激活素 A 受体 1B 型

种属: Rattus norvegicus

同用名: Skr2

基因 ID: 29381 | 基因类型: protein coding

关于 Acvr1b

Primary_assembly 7: 132,286,275-132,329,673 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 271 orthologues, 11 paralogues and is associated with 10 phenotypes. Biased expression in Kidney (RPKM 81.1), Brain (RPKM 55.3) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动；激活素结合活性；和激活素受体活性，I 型。预计有助于激活素激活受体活性和生长因子结合活性。参与中枢神经系统发育；主要女性性特征的发展；氮化合物代谢过程的正向调控。预测位于细胞表面和胞质溶胶中。预计是质膜的组成部分。预计是激活素受体复合物的一部分。预计在质膜上有活性。该基因的人类直系同源物与胰腺癌有关。与人类 ACVR1B（1B 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; activin binding activity; and activin receptor activity, type I. Predicted to contribute to activin-activated receptor activity and growth factor binding activity. Involved in central nervous system development; development of primary female sexual characteristics; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cell surface and cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ACVR1B (Activin A receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1b 基因产物(1)

mRNA Protein Name
NM_199230.2 NP_954700.1 activin receptor type-1B precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activin receptor signaling pathway IMP
IMP: 通过突变表型推断
17040568 RGD
involved in cardiac fibroblast cell development IMP
IMP: 通过突变表型推断
27477354 RGD
involved in development of primary female sexual characteristics IEP
IEP: 通过表达模式推断
11897700 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
27477354 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17040568 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
22332899 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Acvr1b 蛋白结构

Activin_recp

Activin_recp: pfam01064 (31 - 103)

GS

GS: smart00467 (176 - 206)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (210 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

activin receptor type-1B

ACTR-IB

ALK-4

Serine/threonine-protein kinase receptor R2

activin A receptor, type IB

activin receptor type IB

activin receptor-like kinase 4

重组 Acvr1b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76718 Activin RIB/ALK-4 Protein, Rat (HEK293, Fc) P80202 (S24-E126) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acvr1b NCBI NCBI:91
Mus musculus Acvr1b NCBI NCBI:11479
Macaca mulatta Acvr1b NCBI NCBI:696587
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