2. Gene
  3. Bace1 - beta-secretase 1 Gene

Bace1 - beta-secretase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：β-分泌酶 1

种属: Rattus norvegicus

同用名: Bace

基因 ID: 29392 | 基因类型: protein coding

关于 Bace1

Primary_assembly 8: 46,142,116-46,165,876 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 222.4), Heart (RPKM 151.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动肽酶活性。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；细胞对金属离子的反应；和检测涉及疼痛感官知觉的机械刺激。位于多种细胞成分中，包括高尔基体；细胞质囊泡；和神经细胞体。用于研究痴呆症。阿尔茨海默病的生物标志物；感觉周围神经病变;和短暂性脑缺血。该基因的人类直系同源物与阿尔茨海默病有关。与人类 BACE1（β-分泌酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables peptidase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to metal ion; and detection of mechanical stimulus involved in sensory perception of pain. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (Beta-secretase 1). [provided by Alliance of Genome Resources, Apr 2022]

Bace1 基因产物(1)

mRNA Protein Name
NM_019204.2 NP_062077.1 beta-secretase 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
10531052 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta metabolic process IMP
IMP: 通过突变表型推断
10531052 RGD
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
26984601 RGD
involved in cellular response to copper ion IEP
IEP: 通过表达模式推断
18583042 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
18583042 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
28012171 RGD
involved in prepulse inhibition IMP
IMP: 通过突变表型推断
28281673 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
29908845 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
26552445 RGD
located in dendrite IDA
IDA: 通过直接分析推断
26552445 RGD
located in endosome IDA
IDA: 通过直接分析推断
10531052 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
26552445 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
26296617 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bace1 蛋白结构

beta_secretase_like

beta_secretase_like: cd05473 (71 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
蛋白主名 其他名称

beta-secretase 1

ASP2

asp 2

aspartyl protease 2

beta-site APP cleaving enzyme 1

beta-site amyloid precursor protein cleaving enzyme 1

memapsin-2

membrane-associated aspartic protease 2

相关产品

Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-100740 Lanabecestat Inhibitor 99.67% Phase 3
HY-13240 LY2886721 Inhibitor 99.74% Phase 2
HY-114245 Se-Methylselenocysteine Inhibitor ≥98.0% Phase 1
HY-10472 LY2811376 Inhibitor 99.89% Phase 1
HY-109052 Atabecestat Inhibitor 99.77% Phase 1
HY-100182 BACE1-IN-1 Inhibitor 99.02% Phase 1
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0226A Epiberberine chloride Inhibitor 99.02% 否
HY-15908 BCA Inhibitor 99.76% 否
HY-136742 BACE2-IN-1 Inhibitor 99.4% 否
HY-N1255 Scoulerine Inhibitor 99.27% 否
HY-100740C (1α,1'S,4β)-Lanabecestat Inhibitor 96.01% 否
HY-111383 LX2343 Inhibitor 99.80% 否
HY-N0226 Epiberberine Inhibitor 98.46% 否
HY-N2284 Sophoflavescenol Inhibitor 98.15% 否
HY-128594 BACE1-IN-4 Inhibitor / 否
HY-130244 BACE1-IN-5 Inhibitor / 否
HY-128774 AM-6494 Inhibitor / 否
HY-144741 BACE1-IN-9 Inhibitor / 否
HY-P3426 BACE1-IN-10 Inhibitor / 否
HY-139720 β-Secretase Inhibitor III Inhibitor / 否
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / 否
HY-12938 AMG-8718 Inhibitor / 否
HY-149211 AChE/BChE-IN-12 Inhibitor / 否
HY-161359 BACE1-IN-14 Inhibitor / 否
HY-122080 Memoquin Inhibitor / 否
HY-151348 BACE1-IN-11 Inhibitor / 否
HY-P2713 OM99-2 Inhibitor / 否
HY-164956 TB-9 Inhibitor / 否
HY-164958 TB-11 Inhibitor / 否
HY-112444 BACE1-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bace1 NCBI NCBI:23621
Mus musculus Bace1 NCBI NCBI:23821
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