1. Gene
  2. Lbp - lipopolysaccharide binding protein Gene

Lbp - lipopolysaccharide binding protein Gene

中文名称:脂多糖结合蛋白

种属: Rattus norvegicus

同用名: Bpifd2

基因 ID: 29469 | 基因类型: protein coding

关于 Lbp

Primary_assembly 3: 146,954,015-146,981,586 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 104 orthologues, 12 paralogues and is associated with 18 phenotypes. Biased expression in Liver (RPKM 34.4), Heart (RPKM 58.6) and 5 other tissues.

功能概要

该基因编码的蛋白可启动脂多糖结合活性。参与多个过程,包括肝脏发育;巨噬细胞活化的正调节;吞噬作用和吞噬作用的正调节。位于细胞外空间。用于研究肥胖。肝硬化生物标志物;梗阻性黄疸;和牙周炎。与人类 LBP(脂多糖结合蛋白)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables lipopolysaccharide binding activity. Involved in several processes, including liver development; positive regulation of macrophage activation; and positive regulation of phagocytosis, engulfment. Located in extracellular space. Used to study obesity. Biomarker of liver cirrhosis; obstructive jaundice; and periodontitis. Orthologous to human LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Lbp 基因产物(1)

mRNA Protein Name
NM_017208.2 NP_058904.2 lipopolysaccharide-binding protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipopolysaccharide binding IDA
IDA: 通过直接分析推断
22580761 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in liver development IEP
IEP: 通过表达模式推断
20978830 RGD
involved in positive regulation of macrophage activation IDA
IDA: 通过直接分析推断
10733550 RGD
involved in positive regulation of phagocytosis, engulfment IDA
IDA: 通过直接分析推断
11104656 RGD
involved in regulation of membrane permeability IMP
IMP: 通过突变表型推断
17446308 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
23277536 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
22580761 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Lbp 蛋白结构

BPI1

BPI1: cd00025 (30 - 251)

LBP_BPI_CETP_C

LBP_BPI_CETP_C: pfam02886 (240 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
蛋白主名 其他名称

lipopolysaccharide-binding protein

BPI fold containing family D, member 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lbp NCBI NCBI:3929
Macaca fascicularis Lbp NCBI NCBI:102124806
Mus musculus Lbp NCBI NCBI:16803
Macaca mulatta Lbp NCBI NCBI:706109