1. Gene
  2. LBP - lipopolysaccharide binding protein Gene

LBP - lipopolysaccharide binding protein Gene

中文名称:脂多糖结合蛋白

种属: Homo sapiens

同用名: BPIFD2

基因 ID: 3929 | 基因类型: protein coding

关于 LBP

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,346,482-38,377,013 (from NCBI)

This gene has 1 transcript (splice variant), 104 orthologues and 12 paralogues. Restricted expression toward liver (RPKM 139.3).

功能概要

由该基因编码的蛋白质参与对革兰氏阴性细菌感染的急性期免疫反应。革兰氏阴性菌在其细胞外壁上含有糖脂、脂多糖 (LPS) 。与杀菌通透性增加蛋白 (BPI) 一起,编码的蛋白结合 LPS 并与 CD14 受体相互作用,可能在调节 LPS 依赖性单核细胞反应中发挥作用。对小鼠的研究表明,编码的蛋白质是对 LPS 的快速急性期反应所必需的,但不是从循环中清除 LPS 所必需的。该蛋白是结构和功能相关蛋白家族的一部分,包括 BPI、血浆胆固醇酯转运蛋白 (CETP) 和磷脂转运蛋白 (PLTP) 。[RefSeq 提供,2012 年 4 月]

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative Bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

LBP 基因产物(1)

mRNA Protein Name
NM_004139.5 NP_004130.2 lipopolysaccharide-binding protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IPI
IPI: 通过物理相互作用推断
15294986 GOA
enables lipopeptide binding IDA
IDA: 通过直接分析推断
15294986 GOA
enables lipopolysaccharide binding IDA
IDA: 通过直接分析推断
12594207 GOA
enables lipopolysaccharide binding IMP
IMP: 通过突变表型推断
24120359 GOA
enables lipoteichoic acid binding IDA
IDA: 通过直接分析推断
12594207 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute-phase response IEP
IEP: 通过表达模式推断
12932360 GOA
involved in cell surface pattern recognition receptor signaling pathway IDA
IDA: 通过直接分析推断
15294986 GOA
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
12594207 GOA
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
24120359 GOA
acts upstream of or within cellular response to lipoteichoic acid IDA
IDA: 通过直接分析推断
12594207 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
11528597 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
12932360 GOA
involved in detection of molecule of bacterial origin IDA
IDA: 通过直接分析推断
11528597 GOA
involved in lipopolysaccharide transport IDA
IDA: 通过直接分析推断
8985160 GOA
involved in lipopolysaccharide-mediated signaling pathway IDA
IDA: 通过直接分析推断
8409400 GOA
involved in macrophage activation involved in immune response IMP
IMP: 通过突变表型推断
24120359 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
11739189 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
8409400 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
8409400 GOA
involved in positive regulation of macrophage activation IDA
IDA: 通过直接分析推断
8409400 GOA
involved in positive regulation of toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
11528597 GOA
acts upstream of or within positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
12594207 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
8409400 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
24120359 GOA
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
8409400 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
11528597 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
2402637 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

lipopolysaccharide-binding protein

BPI fold containing family D, member 2

LBP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LBP P18428 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
种属内
LBP P18428 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
种属内
LBP P18428 BDNF Homo sapiens P23560-2
Y2H Array
32814053
种属内
LBP P18428 PRDX4 Homo sapiens Q13162
Y2H
21988832
种属内
LBP P18428 PRDX4 Homo sapiens Q13162
Confocal
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LBP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70313 LBP Protein, Human (HEK293, His) P18428 (A26-V481) ≥95%
HY-P78664 LBP Protein, Human (I465F, HEK293, His) P18428-1 (A26-V481, I465F) ≥95%

关联疾病

疾病名称 别名
Alcoholic Hepatitis

Acute Alcoholic Hepatitis

Acute Alcoholic Liver Disease

Hepatitis, Alcoholic

Hepatitis Alcoholic

Ah - [Alcoholic Hepatitis]

Ethanol Hepatitis

Toxic Pneumonitis

Acute Chemical Fume Pulmonary Edema

Acute Chemical Pulmonary Edema

Acute Pulmonary Edema Due To Fumes And/Or Vapors

Peritonitis

Retractile Mesenteritis

Sclerosing Mesenteritis

Acute Generalized Peritonitis

Primary Bacterial Peritonitis

Idiopathic Sclerosing Mesenteritis

Mesenteric Panniculitis

Peritoneal Retractile Mesenteritis

Liposclerotic Mesenteritis

Mesenteric Fibromatosis

Mesenteric Lipodystrophy

Mesenteric Lipogranuloma

Fibromatosis, Abdominal

Peritoneum Inflammation

Peritonitis Of Undetermined Cause

Peritonitis Of Unspecified Cause

Pelviperitonitis

Pelvic Peritonitis, Nos

Generalised Peritonitis Nos

Abdominal Peritonitis

Acute Idiopathic Peritonitis

Acute Lesser Sac Peritonitis

Acute Peritoneal Inflammation

Diffuse Peritonitis

Peritoneal Inflammation

Acute Primary Peritonitis

Pneumococcal Peritonitis

Reactive Arthritis

Postdysenteric Arthropathy

Reiter Disease

Pira

Reiter Syndrome

Reiters Syndrome

Arthritis, Reactive

Fiessinger Leroy Reiter Syndrome

Post-Bacterial Arthropathy

Reiter'S Disease

Post-Infectious Arthritis

Post-Infectious Reactive Arthropathy

Reiter'S Syndrome

Arthritis Urethritica

Fiessinger-Leroy Disease

Polyarthritis Enterica

Venereal Arthritis

Arthritis Reactive

Post-Dysenteric Arthropathy

Arthritis, Venereal

Mastitis

Breast Inflammation

Inflammatory Breast Disease

Inflammatory Disease Of Breast

Inflammation Of Non-Human Mammary Gland

Inflammatory Disorder Of Breast

Mastitis Nos

Acute Mastitis Nos

Acute Nonpuerperal Mastitis

Nonpuerperal Mastitis Nos

Subacute Mastitis Nos

Toxic Shock Syndrome

Septic Shock

Toxic Shock

Tss

Shock, Septic

Staphylococcal Toxic Shock Syndrome

Tss - [Toxic Shock Syndrome]

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Ards

Non-Cardiogenic Pulmonary Edema

Acute Lung Injury

Respiratory Distress Syndrome, Adult

Shock Lung

Acute Respiratory Distress

Respiratory Distress Syndrome

Adult Rds

Ali

Increased-Permeability Pulmonary Edema

Stiff Lung

Respiratory Distress Syndrome Adult

Appendicitis

Acute Appendicitis

Acute Appendicitis With Generalized Peritonitis

Acute Appendicitis Nos

Acute Appendicitis With Peritoneal Abscess

Appendiceal Inflammation

Appendicitis, Unqualified

Acute Appendix Inflammation

Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation

Acute Appendicitis With Free Peritonitis

Acute Appendicitis With Free Perforation To The Abdominal Cavity

Perforated Appendix With Generalised Peritonitis

Appendicitis With Perforation And Free Pus In The Peritoneal Cavity

Perforated Appendix With Localised Peritonitis

Acute Appendicitis With Contained Perforation To A Localised Abscess

Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation

Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation

Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess

Appendicitis With Abscess

Appendicitis With Peritoneal Abscess

Ruptured Appendix Nos

Acute Appendicitis With No Perforation Or Abscess And No Visible Pus

Acute Appendicitis With No Specification If Perforated Or Not

Acute Appendicitis With Phlegmone

Endocarditis
Liver Cirrhosis

Cirrhosis

Cirrhosis Of Liver

CIRRH

Cryptogenic Cirrhosis

Cirrhosis, Cryptogenic

Cirrhosis Nos

Pneumonia

Acute Pneumonia

Pneumonias

Infectious Pneumonia

Pn - [Pneumonia]

Lobar Pneumonia Nos

Multifocal Pneumonia

Orthostatic Pneumonia

Pneumonia Nos

Chronic Pneumonia Nos

Atypical Pneumonia

Passive Pneumonia

Purulent Pneumonia

Interstitial Lobar Pneumonia

Pneumonia, Unspecified

Pneumonia Due To Chlamydia

Pneumonia Due To Chlamydia Pneumoniae

Pneumonia Due To E. Coli

Escherichia Coli Lobar Pneumonia

Pneumonia Due To H. Influenzae

Pneumonia Due To Hemophilus Influenzae

Bronchopneumonia Due To H. Influenzae

Haemophilus Influenzae Lobar Pneumonia

Bronchopneumonia Due To Hemophilus Influenzae

Pseudomonal Pneumonia

Pseudomonas Pneumonia

Pseudomonas Lobar Pneumonia

Staphylococcal Pneumonia

Staphylococcus Pneumonia

Acute Staphylococcal Pneumonia

Staphylococcal Double Pneumonia

Staphylococcal Lobar Pneumonia

Staphylococcal Purulent Pneumonia

Staphylococcal Bronchopneumonia

Pneumococcal Pneumonia

Pneumococcus Pneumonia

Bronchopneumonia Due To S. Pneumoniae

Pneumococcal Lobar Pneumonia

Streptococcal Pneumoniae Pneumonia

Streptococcus Pneumoniae Lobar Pneumonia

Pyemic Pneumococcal Embolism With Pneumonia

Bronchopneumonia Due To Streptococcus Pneumoniae

Pneumonia Due To Streptococcus, Group B

Group B Streptococcal Pneumonia

Adenovirus Pneumonia

Adenoviral Pneumonia

Adenovirus Viral Pneumonia

Pneumonia Respiratory Syncytial Viral

Parainfluenza Viral Pneumonia

Parainfluenzal Pneumonia

Parainfluenza Virus Pneumonia

Human Metapneumovirus Pneumonia

Human Metapneumovirus Infection Resulting In Pneumonia

Pneumocystis Pneumonia

Plasma Cells Pneumonia

Leptospirosis

Fort Bragg Fever

Weil Disease

Leptospirosis Icterohaemorrhagica

Nanukayami Fever

Canicola Fever

Hemorrhagic Jaundice

Mud Fever

Stuttgart Disease

Swamp Fever

Rat Catcher'S Yellows

Spirochetal Jaundice

Weil'S Disease

Cane-Cutter Fever

Icterohemorrhagic Fever

Rice-Field Fever

Swineherd'S Disease

Weil Syndrome

Nanukayami

Canine Leptospirosis

Equine Infectious Anemia

Leptospirosis Canicola

Fever Due To Leptospira Autumnalis

Gikiyami

Leptospira Interrogans Autumnalis Infection

Leptospira Interrogans Canicola Infection

Leptospira Interrogans Hebdomadis Infection

Leptospira Interrogans Pomona Infection

Nanukayami Disease

Pretibial Fever

Seven-Day Fever

Eia - [Equine Infectious Anaemia]

Leptospira Interrogans Infection

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Filariasis

Disease Due To Superfamily Filarioidea

Bancroftian Filarial Fever

Mumu

Wanganga

Bancroftian Filariasis

Wuchereriosis

Brugiosis

Malayan Filariasis

Meningitis

Streptococcal Meningitis

Acute Streptococcal Meningitis

Staphylococcal Meningitis

Adenoviral Meningitis

Influenza Meningitis

Influenzal Meningitis

Meningitis Due To H. Influenzae

Cryptococcal Meningitis

Fungal Meningitis Due To Cryptococcus Neoformans

Cryptococcosis Meningitis

Cryptococcus Meningitis

Cryptococcal Meningoencephalitis

Meningitis Due To Cryptococcus

Mumps Virus Meningitis

Mumps Meningitis

Bacteremia 2

Bacteremia

Bacteremia, Susceptibility To, 2

BACTS2

Bacteremia, Susceptibility To

Bacteremia, Susceptibility To, Type 2

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LBP RGD RGD:61865
Mus musculus LBP MGD MGI:1098776
Bos taurus LBP VGNC VGNC:56192
Macaca mulatta LBP VGNC VGNC:74240
Macaca fascicularis LBP NCBI NCBI:102124806
Others LBP NCBI