2. Gene
  3. P2RX7 - purinergic receptor P2X 7 Gene

P2RX7 - purinergic receptor P2X 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X 7

种属: Rattus norvegicus

基因 ID: 29665 | 基因类型: protein coding

关于 P2RX7

Primary_assembly 12: 33,879,745-33,934,619 reverse strand.mRatBN7.2:CM026985.1

This gene has 6 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 9 phenotypes. Biased expression in Liver (RPKM 74.), Lung (RPKM 67.2) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；细胞外 ATP 门控阳离子通道活性；和金属离子结合活性。涉及多个流程，包括ATP出口；气泡组装；和大分子代谢过程的正向调控。位于多个细胞成分中，包括泡；膜筏；和终端按钮。是核内膜的组成部分。部分含蛋白质复合物。与人 P2RX7（嘌呤能受体 P2X 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and metal ion binding activity. Involved in several processes, including ATP export; bleb assembly; and positive regulation of macromolecule metabolic process. Located in several cellular components, including bleb; membrane raft; and terminal bouton. Is integral component of nuclear inner membrane. Part of protein-containing complex. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2RX7 基因产物(1)

mRNA Protein Name
NM_019256.2 NP_062129.1 P2X purinoceptor 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
17394459 RGD
enables channel activity IDA
IDA: 通过直接分析推断
18519738 RGD
enables copper ion binding IDA
IDA: 通过直接分析推断
17394459 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
8614837 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18938136 RGD
enables magnesium ion binding IDA
IDA: 通过直接分析推断
17394459 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17036048 RGD
enables protein serine/threonine kinase activator activity IMP
IMP: 通过突变表型推断
15023862 RGD
enables purinergic nucleotide receptor activity IDA
IDA: 通过直接分析推断
8614837 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
19416975 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
17785580 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
17394459 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP export IMP
IMP: 通过突变表型推断
31630543 RGD
involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
12857854 RGD
involved in bleb assembly IDA
IDA: 通过直接分析推断
12857854 RGD
involved in cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
12857854 RGD
involved in extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
8614837 RGD
involved in membrane depolarization IDA
IDA: 通过直接分析推断
8614837 RGD
involved in neuronal action potential IDA
IDA: 通过直接分析推断
17394459 RGD
involved in pore complex assembly IDA
IDA: 通过直接分析推断
15883745 RGD
involved in pore complex assembly IMP
IMP: 通过突变表型推断
15883745 RGD
involved in positive regulation of cytoskeleton organization IDA
IDA: 通过直接分析推断
12857854 RGD
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
15883745 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
15883745 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
15023862 RGD
involved in regulation of presynaptic dense core granule exocytosis EXP
EXP: 通过实验结果推断
24037803 RGD
involved in regulation of presynaptic dense core granule exocytosis IDA
IDA: 通过直接分析推断
24037803 RGD
involved in regulation of sodium ion transport IDA
IDA: 通过直接分析推断
17785580 RGD
involved in response to ATP IDA
IDA: 通过直接分析推断
8614837 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bleb IDA
IDA: 通过直接分析推断
12857854 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
12857854 RGD
located in nuclear envelope IDA
IDA: 通过直接分析推断
12422208 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
12857854 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
19416975 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
16018975 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2RX7 蛋白结构

P2X_receptor

P2X_receptor: pfam00864 (10 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
蛋白主名 其他名称

P2X purinoceptor 7

ATP receptor

P2X purinoceptor 7-like

P2X7 purinoceptor

P2Z receptor

purinergic receptor P2X, ligand-gated ion channel, 7

purinergic receptor P2X7

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09911 P2RX7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09912 P2rx7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09913 P2RX7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2RX7 NCBI NCBI:5027
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