EEF2K - eukaryotic elongation factor 2 kinase Gene

中文名称：真核细胞延伸因子 2 激酶

种属: Homo sapiens

同用名: eEF-2K; CaMKIII; HSU93850

基因 ID: 29904 | 基因类型: protein coding

关于 EEF2K

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:22,206,278-22,288,738 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 207 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues.

功能概要

该基因在钙调蛋白介导的信号通路中编码一种高度保守的蛋白激酶，该通路将细胞表面受体的激活与细胞分裂联系起来。该激酶参与蛋白质合成的调节。它使真核生物延伸因子 2 (EEF2) 磷酸化，从而抑制 EEF2 功能。这种激酶的活性在许多癌症中增加，可能是抗癌治疗的有效靶标。[RefSeq 提供，2008 年 7 月]

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

EEF2K 基因产物(1)

mRNA	Protein	Name
NM_013302.5	NP_037434.2	eukaryotic elongation factor 2 kinase

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calmodulin binding	IDA IDA: 通过直接分析推断	9144159	GOA
enables elongation factor-2 kinase activity	IDA IDA: 通过直接分析推断	9144159	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	9144159	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EEF2K 蛋白结构

Alpha_kinase

Sel1

0
200
400
600
725 a.a.

蛋白主名

其他名称

eukaryotic elongation factor 2 kinase

alternative protein EEF2K

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-110096	A-484954	Inhibitor	99.34%	否
HY-100576	NH125	Inhibitor	99.81%	否
HY-146324	PROTAC eEF2K degrader-1		98.64%	否
HY-112393	TX-1918	Inhibitor	/	否
HY-121828	TX-1123	Inhibitor	/	否
HY-123024	Cefatrizine		/	否
HY-RS04181	EEF2K Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	EEF2K	VGNC	VGNC:72098
Felis catus	EEF2K	VGNC	VGNC:61734
Rattus norvegicus	EEF2K	RGD	RGD:2538
Mus musculus	EEF2K	MGD	MGI:1195261
Bos taurus	EEF2K	VGNC	VGNC:28336
Canis familiaris	EEF2K	VGNC	VGNC:40210
Others	EEF2K	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EEF2K - eukaryotic elongation factor 2 kinase Gene

关于 EEF2K

功能概要

EEF2K 基因产物(1)

EEF2K 蛋白结构

关联疾病

直系同源

热门区域

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EEF2K - eukaryotic elongation factor 2 kinase Gene

关于 EEF2K

功能概要

EEF2K 基因产物(1)

EEF2K 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z