PNMA3 - PNMA family member 3 Gene

中文名称：PNMA 家族成员 3

种属: Homo sapiens

同用名: MA3; MA5

关于 PNMA3

功能概要

该基因编码的蛋白质属于副肿瘤抗原 MA (PNMA) 家族，与逆转录病毒 Gag 蛋白具有同源性。 PNMA 抗原在大脑中高度表达，也在一系列与严重神经表型相关的肿瘤中表达。 PMID:16407312 报告了该基因中存在功能性 -1 核糖体移码信号 (由七核苷酸移位基序和 3' 假结结构组成) ，但是移码产物尚未表征。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]