Tbk1 - TANK-binding kinase 1 Gene

中文名称：TANK 结合激酶 1

种属: Rattus norvegicus

关于 Tbk1

功能概要

预计该基因编码的蛋白具有多种功能，包括相同的蛋白质结合活性；磷蛋白结合活性；和蛋白磷酸酶结合活性。预计将参与多个过程，包括防御反应的积极调节；蛋白质磷酸化；和基因表达的调控。预计在几个过程的上游或内部起作用，包括对革兰氏阳性细菌的防御反应；树突状细胞增殖；和干扰素-β产生的正调节。预测位于核质中。预计在细胞质中有活性。该基因的人类直系同源物与脑部疾病和额颞叶痴呆和/或肌萎缩侧索硬化症 4 有关。与人类 TBK1（TANK 结合激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including identical protein binding activity; phosphoprotein binding activity; and protein Phosphatase binding activity. Predicted to be involved in several processes, including positive regulation of defense response; protein phosphorylation; and regulation of gene expression. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]