1. Gene
  2. PILRB - paired immunoglobin like type 2 receptor beta Gene

PILRB - paired immunoglobin like type 2 receptor beta Gene

中文名称:配对免疫球蛋白样 2 型受体 β

种属: Homo sapiens

同用名: FDFACT1; FDFACT2

基因 ID: 29990 | 基因类型: protein coding

关于 PILRB

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,358,117-100,367,831 (from NCBI)

This gene has 13 transcripts (splice variants), 20 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.6), spleen (RPKM 35.1) and 25 other tissues.

功能概要

成对的免疫球蛋白样 2 型受体由高度相关的激活受体和抑制受体组成,它们参与免疫系统许多方面的调节。配对的免疫球蛋白样受体基因位于 7 号染色体上的串联头尾方向。该基因编码受体对的激活成员,并包含相对于其抑制对应物 (PILRA) 的截短细胞质尾部,具有带有免疫受体酪氨酸抑制 (ITIM) 基序的长胞质尾巴。该基因被认为是由抑制性 PILRA 基因的复制产生的,并进化为获得其激活功能。[RefSeq 提供,2013 年 6 月]

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

PILRB 基因产物(2)

mRNA Protein Name
NM_001371931.2 NP_001358860.1 paired immunoglobulin-like type 2 receptor beta isoform 1 precursor
NM_178238.4 NP_839956.1 paired immunoglobulin-like type 2 receptor beta isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10660620 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PILRB 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (35 - 148)

  • 0
  • 100
  • 200
  • 227 a.a.
蛋白主名 其他名称

paired immunoglobulin-like type 2 receptor beta

activating receptor PILR-beta

重组 PILRB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77463 PILR-beta Protein, Human (HEK293, His) Q9UKJ0-1 (Q20-A189) ≥95%

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

Ibd25

Inflammatory Bowel Disease 25, Autosomal Recessive

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PILRB RGD RGD:1584675
Mus musculus PILRB NCBI