2. Gene
  3. Arpc2 - actin related protein 2/3 complex, subunit 2 Gene

Arpc2 - actin related protein 2/3 complex, subunit 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：肌动蛋白相关蛋白 2/3 复合物，亚基2

种属: Rattus norvegicus

同用名: p34Arc

基因 ID: 301511 | 基因类型: protein coding

关于 Arpc2

Primary_assembly 9: 75,820,770-75,851,471 forward strand.mRatBN7.2:CM026982.1

This gene has 5 transcripts (splice variants), 241 orthologues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 125.8), Thymus (RPKM 929.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 AP-1 适配器复合体绑定活动； ATP酶结合活性；和 Arp2/3 复合物结合活性。参与多个过程，包括细胞对生长因子刺激的反应；细胞对雷帕霉素的反应；和细胞成分组织的正向调节。位于几种细胞成分中，包括肌动蛋白细胞骨架；树突;和远端轴突。丝状肌动蛋白的一部分。硅肺病的生物标志物。与人类 ARPC2（肌动蛋白相关蛋白 2/3 复合亚基 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including AP-1 adaptor complex binding activity; ATPase binding activity; and Arp2/3 complex binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to rapamycin; and positive regulation of cellular component organization. Located in several cellular components, including actin cytoskeleton; dendrite; and distal axon. Part of filamentous actin. Biomarker of silicosis. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Arpc2 基因产物(1)

mRNA Protein Name
NM_001106919.1 NP_001100389.1 actin-related protein 2月3日 complex subunit 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables AP-1 adaptor complex binding IDA
IDA: 通过直接分析推断
22689987 RGD
enables ATPase binding IPI
IPI: 通过物理相互作用推断
18297063 RGD
enables Arp2/3 complex binding IDA
IDA: 通过直接分析推断
22689987 RGD
enables glutamate receptor binding IPI
IPI: 通过物理相互作用推断
18297063 RGD
enables kinesin binding IDA
IDA: 通过直接分析推断
22689987 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17456547 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17350576 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to epidermal growth factor stimulus IMP
IMP: 通过突变表型推断
15252126 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
24152438 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
10797548 RGD
involved in cellular response to platelet-derived growth factor stimulus IDA
IDA: 通过直接分析推断
22619279 RGD
involved in cellular response to rapamycin IDA
IDA: 通过直接分析推断
11598004 RGD
involved in positive regulation of barbed-end actin filament capping IMP
IMP: 通过突变表型推断
15252126 RGD
involved in positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
18256280 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
15252126 RGD
involved in positive regulation of podosome assembly IMP
IMP: 通过突变表型推断
17224451 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
20739464 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
24152438 RGD
involved in protein kinase C signaling IDA
IDA: 通过直接分析推断
16027158 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
20739464 RGD
involved in response to silicon dioxide IEP
IEP: 通过表达模式推断
18685790 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
18509026 RGD
located in actin filament branch point IDA
IDA: 通过直接分析推断
18256280 RGD
located in apical dendrite IDA
IDA: 通过直接分析推断
18509026 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
18509026 RGD
located in cell leading edge IDA
IDA: 通过直接分析推断
16027158 RGD
located in cell surface IDA
IDA: 通过直接分析推断
11598004 RGD
located in concave side of sperm head IDA
IDA: 通过直接分析推断
23403943 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
18509026 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
18509026 RGD
part of filamentous actin IDA
IDA: 通过直接分析推断
10797548 RGD
located in growth cone IDA
IDA: 通过直接分析推断
10797548 RGD
located in lamellipodium IDA
IDA: 通过直接分析推断
15684033 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
18509026 RGD
located in peripheral region of growth cone IDA
IDA: 通过直接分析推断
18256280 RGD
located in podosome core IDA
IDA: 通过直接分析推断
17224451 RGD
located in podosome ring IDA
IDA: 通过直接分析推断
17224451 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
18509026 RGD
located in ruffle membrane IDA
IDA: 通过直接分析推断
17224451 RGD
located in secretory granule IDA
IDA: 通过直接分析推断
14617808 RGD
located in ventral surface of cell IDA
IDA: 通过直接分析推断
11598004 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Arpc2 蛋白结构

P34-Arc

P34-Arc: pfam04045 (56 - 283)

  • 0
  • 100
  • 200
  • 300 a.a.
蛋白主名 其他名称

actin-related protein 2/3 complex subunit 2

arp2/3 complex 34 kDa subunit

p34-ARC

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-114657A Benproperine phosphate Inhibitor 99.35% 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01015 ARPC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01016 Arpc2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01017 Arpc2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Arpc2 NCBI NCBI:10109
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