2. Gene
  3. ARPC2 - actin related protein 2/3 complex subunit 2 Gene

ARPC2 - actin related protein 2/3 complex subunit 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌动蛋白相关蛋白 2/3 复合亚基 2

种属: Homo sapiens

同用名: ARC34; PRO2446; p34-Arc; PNAS-139

基因 ID: 10109 | 基因类型: protein coding

关于 ARPC2

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,217,189-218,254,348 (from NCBI)

This gene has 18 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues.

功能概要

该基因编码人类 Arp2/3 蛋白复合物的七个亚基之一。 Arp2/3 蛋白复合物与细胞中肌动蛋白聚合的控制有关，并在进化过程中得以保存。该基因编码的蛋白质 p34 亚基的确切作用尚未确定。迄今为止，已经表征了两种可变剪接变体。已经描述了额外的可变剪接变体，但尚未确定它们的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

ARPC2 基因产物(4)

mRNA Protein Name
NM_152862.3 NP_690601.1 actin-related protein 2/3 complex subunit 2
XM_017003113.2 XP_016858602.1 actin-related protein 2/3 complex subunit 2 isoform X1
NM_005731.3 NP_005722.1 actin-related protein 2/3 complex subunit 2
XM_047442808.1 XP_047298764.1 actin-related protein 2/3 complex subunit 2 isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to actin filament binding IDA
IDA: 通过直接分析推断
11741539 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11162547 GOA
enables structural constituent of cytoskeleton IDA
IDA: 通过直接分析推断
11741539 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Arp2/3 complex-mediated actin nucleation IDA
IDA: 通过直接分析推断
11741539 GOA
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
18560548 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Arp2/3 protein complex IDA
IDA: 通过直接分析推断
11741539 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
9230079 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARPC2 蛋白结构

P34-Arc

P34-Arc: Arp2/3 complex, 34 kD subunit p34-Arc (56 - 285)

  • 0
  • 100
  • 200
  • 300 a.a.
蛋白主名 其他名称

actin-related protein 2/3 complex subunit 2

ARP2/3 protein complex subunit 34

actin related protein 2/3 complex, subunit 2, 34kDa

arp2/3 complex 34 kDa subunit

testis tissue sperm-binding protein Li 53e

ARPC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARPC2 O15144 CORO1B Homo sapiens Q9BR76
Pull Down
17350576
种属内
ARPC2 O15144 VCL Homo sapiens P18206
Anti Bait CoIP
12473693
种属间: 跨种属相互作用 种属内: 同种属相互作用

ARPC2 抗体

目录号 产品名 应用 反应物种
HY-P82407 ARPC2 Antibody (YA2152) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2
Inclusion Conjunctivitis

Chlamydial Conjunctivitis

Inclusion Blennorrhoea

Paratrachoma

Adult Inclusion Conjunctivitis

Inclusion Blenorrhea

Conjunctivitis, Inclusion

Neonatal Chlamydial Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Chronic Conjunctivitis Due To Chlamydia Trachomatis

Inclusion Conjunctivitis Due To Chlamydia Trachomatis

Acute Follicular Conjunctivitis, Chlamydial

Adult Chlamydial Keratoconjunctivitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-114657A Benproperine phosphate Inhibitor 99.93% 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01015 ARPC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01016 Arpc2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01017 Arpc2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ARPC2 VGNC VGNC:82525
Mus musculus ARPC2 MGD MGI:1923959
Rattus norvegicus ARPC2 RGD RGD:1305848
Macaca mulatta ARPC2 VGNC VGNC:70019
Bos taurus ARPC2 VGNC VGNC:55326
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