2. Gene
  3. CORO1B - coronin 1B Gene

CORO1B - coronin 1B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：冠宁 1B

种属: Homo sapiens

同用名: CORONIN-2

基因 ID: 57175 | 基因类型: protein coding

关于 CORO1B

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,435,510-67,443,809 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 6 paralogues. Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues.

功能概要

coronin 家族的成员，例如 CORO1B，是含有 WD 重复序列的肌动蛋白结合蛋白，可调节细胞运动 (Cai 等人，2005 [PubMed 16027158]) 。[OMIM 提供，2008 年 3 月]

Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

CORO1B 基因产物(2)

mRNA Protein Name
NM_001018070.3 NP_001018080.1 coronin-1B
NM_020441.3 NP_065174.1 coronin-1B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Arp2/3 complex binding IDA
IDA: 通过直接分析推断
16027158 GOA
enables Arp2/3 complex binding IPI
IPI: 通过物理相互作用推断
22619279 GOA
enables actin filament binding IDA
IDA: 通过直接分析推断
17456547 GOA
enables actin filament binding IMP
IMP: 通过突变表型推断
22364218 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
16027158 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16027158 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
18775315 GOA
involved in actin filament branching IDA
IDA: 通过直接分析推断
18775315 GOA
involved in actin filament bundle assembly IDA
IDA: 通过直接分析推断
17456547 GOA
involved in cell migration IDA
IDA: 通过直接分析推断
16027158 GOA
involved in cellular response to platelet-derived growth factor stimulus IMP
IMP: 通过突变表型推断
22619279 GOA
involved in endothelial cell chemotaxis IDA
IDA: 通过直接分析推断
23667561 GOA
involved in endothelial cell chemotaxis IMP
IMP: 通过突变表型推断
23667561 GOA
involved in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
IDA: 通过直接分析推断
17350576 GOA
involved in negative regulation of smooth muscle cell chemotaxis IMP
IMP: 通过突变表型推断
22619279 GOA
involved in positive regulation of lamellipodium morphogenesis IDA
IDA: 通过直接分析推断
17350576 GOA
involved in protein localization to cell leading edge IDA
IDA: 通过直接分析推断
17350576 GOA
involved in ruffle organization IDA
IDA: 通过直接分析推断
16027158 GOA
involved in wound healing IDA
IDA: 通过直接分析推断
23667561 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IDA
IDA: 通过直接分析推断
18775315 GOA
located in cell leading edge IDA
IDA: 通过直接分析推断
16027158 GOA
located in cell periphery IDA
IDA: 通过直接分析推断
22619279 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23667561 GOA
located in cytosol IDA
IDA: 通过直接分析推断
22619279 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
22619279 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22619279 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
15800061 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
16027158 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CORO1B 蛋白结构

DUF1899

DUF1899: Domain of unknown function (DUF1899) (5 - 69)

WD40

WD40: WD domain, G-beta repeat (78 - 110)

WD40

WD40: WD domain, G-beta repeat (123 - 161)

WD40

WD40: WD domain, G-beta repeat (175 - 204)

Trimer_CC

Trimer_CC: Trimerisation motif (259 - 392)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
蛋白主名 其他名称

coronin-1B

coronin, actin binding protein, 1B

关联疾病

疾病名称 别名
Coronin-1a Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03049 CORO1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CORO1B MGD MGI:1345963
Macaca mulatta CORO1B VGNC VGNC:71320
Rattus norvegicus CORO1B RGD RGD:2382
Bos taurus CORO1B VGNC VGNC:27621
Felis catus CORO1B VGNC VGNC:61102
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