1. Gene
  2. CORO1C - coronin 1C Gene

CORO1C - coronin 1C Gene

中文名称:冠宁 1C

种属: Homo sapiens

同用名: HCRNN4

基因 ID: 23603 | 基因类型: protein coding

关于 CORO1C

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,645,109-108,731,518 (from NCBI)

This gene has 19 transcripts (splice variants), 289 orthologues and 6 paralogues. Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues.

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域,通常由 gly-his 和 trp-asp (GH-WD) 括起来,这可能有助于异源三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程,包括细胞周期进程、信号转导、细胞凋亡和基因调控。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供,2013 年 2 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

CORO1C 基因产物(3)

mRNA Protein Name
NM_001105237.2 NP_001098707.1 coronin-1C isoform a
NM_001276471.2 NP_001263400.1 coronin-1C isoform b
NM_014325.4 NP_055140.1 coronin-1C isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IMP
IMP: 通过突变表型推断
22364218 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25074804 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosomal transport IDA
IDA: 通过直接分析推断
30220460 GOA
involved in endosome fission IDA
IDA: 通过直接分析推断
30220460 GOA
involved in endosome membrane tubulation IDA
IDA: 通过直接分析推断
30220460 GOA
involved in membrane fission IDA
IDA: 通过直接分析推断
30220460 GOA
involved in negative regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
19913511 GOA
involved in negative regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
19913511 GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
19913511 GOA
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
19913511 GOA
involved in negative regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
19913511 GOA
involved in neural crest cell migration IMP
IMP: 通过突变表型推断
25074804 GOA
involved in positive regulation of lamellipodium morphogenesis IMP
IMP: 通过突变表型推断
19913511 GOA
involved in regulation of epithelial cell migration IGI
IGI: 通过遗传相互作用推断
19913511 GOA
involved in regulation of focal adhesion assembly IGI
IGI: 通过遗传相互作用推断
19913511 GOA
involved in regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
19913511 GOA
involved in regulation of substrate adhesion-dependent cell spreading IGI
IGI: 通过遗传相互作用推断
19913511 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
22364218 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
30220460 GOA
NOT colocalizes with focal adhesion IDA
IDA: 通过直接分析推断
19913511 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
22364218 GOA
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
25074804 GOA
colocalizes with vesicle IDA
IDA: 通过直接分析推断
25074804 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CORO1C 蛋白结构

DUF1899

DUF1899: Domain of unknown function (DUF1899) (3 - 67)

WD40

WD40: WD domain, G-beta repeat (75 - 108)

WD40

WD40: WD domain, G-beta repeat (121 - 159)

WD40

WD40: WD domain, G-beta repeat (173 - 202)

Trimer_CC

Trimer_CC: Trimerisation motif (256 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
蛋白主名 其他名称

coronin-1C

coronin, actin binding protein, 1C

CORO1C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CORO1C Q9ULV4 CORO1B Homo sapiens Q9BR76
Anti Tag CoIP
28514442
种属内
CORO1C Q9ULV4 CORO1B Homo sapiens Q9BR76
Anti Tag CoIP
33961781
种属内
CORO1C Q9ULV4 CORO1B Homo sapiens Q9BR76
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2

Fcc2

Coca2

Hereditary Nonpolyposis Colorectal Cancer Type 2

Colon Cancer, Familial Nonpolyposis, Type 2

Familial Nonpolyposis Colon Cancer Type 2

Hereditary Non-Polyposis Colorectal Cancer 2

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2

Coronin-1a Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CORO1C MGD MGI:1345964
Macaca mulatta CORO1C VGNC VGNC:71321
Rattus norvegicus CORO1C RGD RGD:1564490
Bos taurus CORO1C VGNC VGNC:27622
Felis catus CORO1C VGNC VGNC:61103
Canis familiaris CORO1C VGNC VGNC:39528