SSH1 - slingshot protein phosphatase 1 Gene

中文名称：弹弓蛋白磷酸酶 1

种属: Homo sapiens

同用名: SSH1L

关于 SSH1

功能概要

该基因编码的蛋白质属于磷酸酶的弹弓同源物 (SSH) 家族，可调节肌动蛋白丝动力学。 SSH 蛋白去磷酸化并激活肌动蛋白结合/解聚因子肌动蛋白丝切蛋白，后者随后与肌动蛋白丝结合并刺激它们的分解。肌动蛋白丝切蛋白被 LIM 结构域激酶 1 (LIMK1) 等激酶失活，后者也可能被 SSH 蛋白去磷酸化和失活。因此，SSH 家族似乎通过重新激活肌动蛋白丝切蛋白在肌动蛋白动力学中发挥作用。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]