Pdcd1 - programmed cell death 1 Gene

中文名称：程序性细胞死亡1

种属: Rattus norvegicus

关于 Pdcd1

功能概要

预计该基因编码的蛋白参与免疫反应的负调控和T细胞凋亡过程的正调控。预计在细胞凋亡过程的负调节上游或负调节内起作用；耐受诱导的负调节；和细胞凋亡过程的正调控。位于质膜。抗基底膜肾小球肾炎生物标志物；牙周炎;和先兆子痫。该基因的人类直系同源物与自身免疫性疾病有关（多个）；乙型肝炎；丙型肝炎;肝细胞癌；和狼疮性肾炎。与人类 PDCD1（程序性细胞死亡 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in negative regulation of immune response and positive regulation of T cell apoptotic process. Predicted to act upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in plasma membrane. Biomarker of anti-basement membrane glomerulonephritis; periodontitis; and pre-eclampsia. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2022]