2. Gene
  3. Pdcd1 - programmed cell death 1 Gene

Pdcd1 - programmed cell death 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：程序性细胞死亡1

种属: Mus musculus

同用名: PD-1; Pdc1; Ly101

基因 ID: 18566 | 基因类型: protein coding

关于 Pdcd1

Chromosome 1: 93,966,027-93,980,278 reverse strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 106 orthologues and is associated with 45 phenotypes. Biased expression in thymus adult (RPKM 7.6), ovary adult (RPKM 3.5) and 3 other tissues.

功能概要

该基因编码的蛋白参与免疫反应的负调节。在细胞凋亡过程的负调控上游或负调控中起作用；耐受诱导的负调节；和细胞凋亡过程的正调控。位于质膜外侧。在视网膜中表达。用于研究扩张型心肌病和系统性红斑狼疮。该基因的人类直系同源物与自身免疫性疾病有关（多个）；乙型肝炎；丙型肝炎;肝细胞癌；和狼疮性肾炎。与人类 PDCD1（程序性细胞死亡 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd1 基因产物(1)

mRNA Protein Name
NM_008798.3 NP_032824.1 programmed cell death protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15568026 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell apoptotic process IMP
IMP: 通过突变表型推断
23636058 MGI
acts upstream of or within negative regulation of B cell apoptotic process IMP
IMP: 通过突变表型推断
23636058 MGI
involved in negative regulation of immune response IMP
IMP: 通过突变表型推断
10485649 MGI
acts upstream of or within negative regulation of tolerance induction IMP
IMP: 通过突变表型推断
23636058 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
23636058 MGI
acts upstream of regulatory T cell apoptotic process IMP
IMP: 通过突变表型推断
23636058 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
15568026 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pdcd1 蛋白结构

IgV_PD1

IgV_PD1: cd16088 (33 - 37)

IgV_PD1

IgV_PD1: cd16088 (33 - 55)

IgV_PD1

IgV_PD1: cd16088 (33 - 144)

IgV_PD1

IgV_PD1: cd16088 (40 - 43)

IgV_PD1

IgV_PD1: cd16088 (47 - 55)

IgV_PD1

IgV_PD1: cd16088 (56 - 62)

IgV_PD1

IgV_PD1: cd16088 (62 - 70)

IgV_PD1

IgV_PD1: cd16088 (63 - 72)

IgV_PD1

IgV_PD1: cd16088 (73 - 82)

IgV_PD1

IgV_PD1: cd16088 (73 - 89)

IgV_PD1

IgV_PD1: cd16088 (85 - 89)

IgV_PD1

IgV_PD1: cd16088 (93 - 127)

IgV_PD1

IgV_PD1: cd16088 (94 - 99)

IgV_PD1

IgV_PD1: cd16088 (104 - 111)

IgV_PD1

IgV_PD1: cd16088 (118 - 128)

IgV_PD1

IgV_PD1: cd16088 (128 - 131)

IgV_PD1

IgV_PD1: cd16088 (130 - 144)

IgV_PD1

IgV_PD1: cd16088 (131 - 144)

  • 0
  • 100
  • 200
  • 288 a.a.
蛋白主名 其他名称

programmed cell death protein 1

mPD-1

programmed cell death 1 protein

protein PD-1

重组 Pdcd1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70639 PD-1 Protein, Mouse (HEK293, Fc) Q02242 (L25-Q167) ≥95%
HY-P70640 PD-1 Protein, Mouse (HEK293, His) Q02242 (L25-Q167) ≥95%
HY-P73724 PD-1 Protein, Mouse (HEK293, His-Fc) NP_032824.1 (L25-Q167) ≥95%
HY-P700808 PD-1 Protein, Mouse (Biotinylated, HEK293, Fc) NP_032824 (L25-Q167) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99698 Lesabelimab Inhibitor 97.34% Phase 2
HY-P99668 Iparomlimab Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10185 PDCD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10186 Pdcd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10187 Pdcd1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10190 PDCD1LG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990072 Lipustobart Inhibitor / 否
HY-P990074 Enlonstobart Inhibitor / 否
HY-P990691 Vilamakitug / 否
HY-P990700 Tobemstomig / 否
HY-P990701 Lomvastomig / 否
HY-P990702 Pradusinstobart / 否
HY-P990704 Rilvegostomig / 否
HY-P990716 Sabestomig / 否
HY-P990912 Cugrastomig / 否
HY-P990486 Anti-PDCD1/PD-1/CD279 Antibody Inhibitor / 否
HY-P990690 Volrustomig / 否
HY-P990722 Danvilostomig / 否
HY-P990740 Fanastomig / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdcd1 NCBI NCBI:5133
Canis familiaris Pdcd1 NCBI NCBI:486213
Macaca fascicularis Pdcd1 NCBI NCBI:102123659
Rattus norvegicus Pdcd1 NCBI NCBI:301626
Macaca mulatta Pdcd1 NCBI NCBI:100135775
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