2. Gene
  3. HCLS1 - hematopoietic cell-specific Lyn substrate 1 Gene

HCLS1 - hematopoietic cell-specific Lyn substrate 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：造血细胞特异性 Lyn 底物 1

种属: Homo sapiens

同用名: HS1; p75; CTTNL; lckBP1

基因 ID: 3059 | 基因类型: protein coding

关于 HCLS1

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,631,399-121,660,903 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in spleen (RPKM 118.5), lymph node (RPKM 107.3) and 16 other tissues.

功能概要

启用 RNA 聚合酶 II 特异性 DNA 结合转录因子结合活性和蛋白激酶结合活性。参与多个过程，包括细胞内信号转导的正向调节；蛋白质磷酸化的正调节；和转录调控，DNA 模板化。位于胞质溶胶中；核;和质膜。转录调节复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

HCLS1 基因产物(2)

mRNA Protein Name
NM_001292041.2 NP_001278970.2 hematopoietic lineage cell-specific protein isoform 2
NM_005335.6 NP_005326.3 hematopoietic lineage cell-specific protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
23001182 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
23001182 GOA
enables signaling adaptor activity IMP
IMP: 通过突变表型推断
23001182 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament organization IDA
IDA: 通过直接分析推断
23001182 GOA
involved in cellular response to cytokine stimulus IMP
IMP: 通过突变表型推断
23001182 GOA
involved in granulocyte colony-stimulating factor signaling pathway IMP
IMP: 通过突变表型推断
23001182 GOA
involved in negative regulation of leukocyte apoptotic process IMP
IMP: 通过突变表型推断
23001182 GOA
involved in nuclear transport IMP
IMP: 通过突变表型推断
23001182 GOA
involved in positive regulation of granulocyte differentiation IMP
IMP: 通过突变表型推断
23001182 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
23001182 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
23001182 GOA
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
23001182 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23001182 GOA
involved in regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
23001182 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23001182 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23001182 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
23001182 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HCLS1 蛋白结构

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (82 - 118)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (119 - 155)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (156 - 192)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (193 - 213)

SH3_1

SH3_1: SH3 domain (434 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
蛋白主名 其他名称

hematopoietic lineage cell-specific protein

HCLS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HCLS1 P14317 SH3BP2 Homo sapiens P78314-3
Validated Y2H
32296183
种属内
HCLS1 P14317 SH3BP2 Homo sapiens P78314-3
Y2H Array
32296183
种属内
HCLS1 P14317 WIPF1 Homo sapiens O43516
Far-WB
21398607
种属内
HCLS1 P14317 WIPF1 Homo sapiens O43516
Pull Down
21398607
种属内
HCLS1 P14317 TERF1 Homo sapiens P54274
Pull Down
21044950
种属内
HCLS1 P14317 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
种属内
HCLS1 P14317 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
种属内
HCLS1 P14317 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
种属内
HCLS1 P14317 SH2D4A Homo sapiens Q9H788
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HCLS1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70289 HCLS1 Protein, Human (HEK293, His) AAH16758.1 (M1-E486) ≥95%

关联疾病

疾病名称 别名
Severe Congenital Neutropenia 3

Kostmann Syndrome

Infantile Agranulocytosis

Kostmann Disease

Scn3

Severe Congenital Neutropenia Type 3
Severe Congenital Neutropenia

Congenital Neutropenia

Neutropenia, Severe Congenital

Congenital Agranulocytosis

Infantile Genetic Agranulocytosis

Kostmann Disease

Kostmann'S Agranulocytosis

Kostmann'S Syndrome

Severe Infantile Genetic Neutropenia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06045 HCLS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HCLS1 VGNC VGNC:41619
Felis catus HCLS1 VGNC VGNC:67543
Bos taurus HCLS1 VGNC VGNC:29775
Rattus norvegicus HCLS1 RGD RGD:1304754
Mus musculus HCLS1 MGD MGI:104568
Macaca mulatta HCLS1 VGNC VGNC:73354
Others HCLS1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z