HDC - histidine decarboxylase Gene

中文名称：组氨酸脱羧酶

种属: Homo sapiens

基因 ID: 3067 | 基因类型: protein coding

关于 HDC

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:50,241,947-50,265,726 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues, 7 paralogues and is associated with 2 phenotypes. Broad expression in gall bladder (RPKM 9.0), stomach (RPKM 6.4) and 14 other tissues.

功能概要

该基因编码 II 组脱羧酶家族的一个成员，并形成同型二聚体，以磷酸吡哆醛依赖性方式将 L-组氨酸转化为组胺。组胺调节多种生理过程，包括神经传递、胃酸分泌、炎症和平滑肌张力。[RefSeq 提供，2010 年 8 月]

This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

HDC 基因产物(2)

mRNA	Protein	Name
NM_001306146.2	NP_001293075.1	histidine decarboxylase isoform 2
NM_002112.4	NP_002103.2	histidine decarboxylase isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histidine decarboxylase activity	IDA IDA: 通过直接分析推断	22767596	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in L-histidine catabolic process	IDA IDA: 通过直接分析推断	22767596	GOA
involved in histamine biosynthetic process	IDA IDA: 通过直接分析推断	22767596	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDC 蛋白结构

Pyridoxal_deC

0
200
400
600
662 a.a.

蛋白主名

其他名称

histidine decarboxylase

HDC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HDC	P19113	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
种属内	HDC	P19113	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Mast Cell Neoplasm

Mastocytoma	Mast Cell Proliferative Disease
Mast Cell Tumor	Benign Mastocytoma

Systemic Mastocytosis

Systemic Mast Cell Disease	Systemic Tissue Mast Cell Disease
Mastocytosis, Systemic	Smcd - Systemic Mast Cell Disease
Smcd	Mast Cell Disease, Systemic
Systemic Mast-Cell Disease	Systemic Mastocytoses
Mastocytosis Systemic	Corneal Dystrophy, Subepithelial Mucinous
Smcd - [Systemic Mast Cell Disease]

Metal Allergy

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Stomach Disease

Gastropathy	Stomach Diseases
Gastric Disease	Stomach Disorder
Gastric Disorder	Stomach Disorders

Tic Disorder

Tics	Behavioral Tic

Peptic Ulcer Disease

Peptic Ulcer	Acute Peptic Ulcer With Hemorrhage
Acute Peptic Ulcer With Hemorrhage And Perforation	Acute Peptic Ulcer Without Hemorrhage And Without Perforation

Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W003445	4-Bromo-3-hydroxybenzoic acid		99.25%	否
HY-115822	α-Fluoromethylhistidine dihydrochloride	Inhibitor	/	否
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	否
HY-RS06091	HDC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W194107	Antitumor agent-152	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HDC	VGNC	VGNC:41625
Rattus norvegicus	HDC	RGD	RGD:2790
Macaca mulatta	HDC	VGNC	VGNC:73360
Mus musculus	HDC	MGD	MGI:96062
Felis catus	HDC	VGNC	VGNC:67550
Bos taurus	HDC	VGNC	VGNC:29784
Others	HDC	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HDC - histidine decarboxylase Gene

关于 HDC

功能概要

HDC 基因产物(2)

HDC 蛋白结构

HDC 蛋白互作信息

关联疾病

直系同源

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HDC - histidine decarboxylase Gene

关于 HDC

功能概要

HDC 基因产物(2)

HDC 蛋白结构

HDC 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z