PIK3R4 - phosphoinositide-3-kinase regulatory subunit 4 Gene

中文名称：磷酸肌醇 3 激酶调节亚基 4

种属: Homo sapiens

同用名: p150; VPS15

基因 ID: 30849 | 基因类型: protein coding

关于 PIK3R4

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:130,678,934-130,746,829 (from NCBI)

This gene has 8 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 9.2), testis (RPKM 8.7) and 25 other tissues.

功能概要

预测启用蛋白质丝氨酸/苏氨酸激酶活性。参与磷脂酰肌醇 3-激酶活性的正向调节；受体分解代谢过程；和胞质分裂的调节。位于晚期核内体和微管细胞骨架中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of phosphatidylinositol 3-kinase activity; receptor catabolic process; and regulation of cytokinesis. Located in late endosome and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

PIK3R4 基因产物(1)

mRNA	Protein	Name
NM_014602.3	NP_055417.1	phosphoinositide 3-kinase regulatory subunit 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14617358	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome maturation	IDA IDA: 通过直接分析推断	10625637	GOA
involved in early endosome to late endosome transport	IDA IDA: 通过直接分析推断	14617358	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	21062745	GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process	IDA IDA: 通过直接分析推断	8999962	GOA
involved in receptor catabolic process	IMP IMP: 通过突变表型推断	20643123	GOA
involved in regulation of autophagy	IDA IDA: 通过直接分析推断	16799551	GOA
involved in regulation of cytokinesis	IMP IMP: 通过突变表型推断	20643123	GOA
involved in regulation of macroautophagy	IDA IDA: 通过直接分析推断	10625637	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in late endosome	IDA IDA: 通过直接分析推断	14617358	GOA
part of phosphatidylinositol 3-kinase complex, class III	IPI IPI: 通过物理相互作用推断	25490155	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIK3R4 蛋白结构

Pkinase

WD40

0
300
600
900
1200
1358 a.a.

蛋白主名

其他名称

phosphoinositide 3-kinase regulatory subunit 4

PI3-kinase p150 subunit

PIK3R4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PIK3R4	Q99570	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	24785657
种属内	PIK3R4	Q99570	NRBF2	Homo sapiens	Q96F24	Y2H Array	32296183
种属内	PIK3R4	Q99570	NRBF2	Homo sapiens	Q96F24	Pull Down	32707033
种属内	PIK3R4	Q99570	NRBF2	Homo sapiens	Q96F24	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

PIK3R4 抗体

目录号	产品名	应用	反应物种
HY-P83078	PI 3 Kinase p150 Antibody (YA2823)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Retinitis Pigmentosa 62

RP62	Retinitis Pigmentosa, Type 62

Myopathy, X-Linked, With Excessive Autophagy

X-Linked Myopathy With Excessive Autophagy	Xmea
MEAX	Vacuolar Myopathy

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Danon Disease

Pseudoglycogenosis Ii	Antopol Disease
Glycogen Storage Disease Iib	Glycogen Storage Disease Type 2b
Glycogen Storage Disease Type Iib	Gsd2b
Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency	Vacuolar Cardiomyopathy And Myopathy X-Linked
Vacuolar Cardiomyopathy And Myopathy, X-Linked	Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly
Gsd2b, Formerly	Gsd Iib, Formerly
Glycogen Storage Cardiomyopathy	Glycogen Storage Disease Limited To The Heart
Pseudoglycogenosis 2	X-Linked Vacuolar Cardiomyopathy And Myopathy
Lysosomal Glycogen Storage Disease With Normal Acid Maltase	Glycogen Storage Disease Due To Lamp-2 Deficiency
Gsd Due To Lamp-2 Deficiency	Glycogenosis Due To Lamp-2 Deficiency
Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity	DAND
Gsd-Iib

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10539	PIK3R4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PIK3R4	RGD	RGD:1311809
Mus musculus	PIK3R4	MGD	MGI:1922919
Bos taurus	PIK3R4	VGNC	VGNC:32895
Felis catus	PIK3R4	VGNC	VGNC:68859
Canis familiaris	PIK3R4	VGNC	VGNC:44561
Macaca mulatta	PIK3R4	VGNC	VGNC:84060

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PIK3R4 - phosphoinositide-3-kinase regulatory subunit 4 Gene

关于 PIK3R4

功能概要

PIK3R4 基因产物(1)

PIK3R4 蛋白结构

PIK3R4 蛋白互作信息

PIK3R4 抗体

关联疾病

直系同源

热门区域

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PIK3R4 - phosphoinositide-3-kinase regulatory subunit 4 Gene

关于 PIK3R4

功能概要

PIK3R4 基因产物(1)

PIK3R4 蛋白结构

PIK3R4 蛋白互作信息

PIK3R4 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z