2. Gene
  3. Chuk - component of inhibitor of nuclear factor kappa B kinase complex Gene

Chuk - component of inhibitor of nuclear factor kappa B kinase complex Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：核因子 κB 激酶复合物抑制因子的成分

种属: Rattus norvegicus

同用名: Ikka; Ikbka

基因 ID: 309361 | 基因类型: protein coding

关于 Chuk

Primary_assembly 1: 242,959,760-242,995,065 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 266 orthologues, 3 paralogues and is associated with 19 phenotypes. Biased expression in Kidney (RPKM 214.9), Liver (RPKM 178.7) and 9 other tissues.

功能概要

有助于 IkappaB 激酶活性。参与多个过程，包括 Rho 蛋白信号转导；对胆囊收缩素的反应；和对脂多糖的反应。位于胞质溶胶和胞内膜界的细胞器中。 IkappaB 激酶复合体的一部分。用于研究肌肉萎缩。结肠炎的生物标志物。该基因的人类直系同源物与胎儿包裹综合征和前列腺癌有关。与人类 CHUK 同源（核因子 kappa B 激酶复合物抑制剂的成分）。 [由基因组资源联盟提供，2022 年 4 月]

Contributes to IkappaB kinase activity. Involved in several processes, including Rho protein signal transduction; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate Cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]

Chuk 基因产物(1)

mRNA Protein Name
NM_001107588.1 NP_001101058.1 inhibitor of nuclear factor kappa-B kinase subunit alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17419723 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to acetate IEP
IEP: 通过表达模式推断
17543437 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
17543437 RGD
involved in response to cholecystokinin IDA
IDA: 通过直接分析推断
12592100 RGD
involved in response to hydroperoxide IEP
IEP: 通过表达模式推断
16028365 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
12361703 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16331110 RGD
involved in skeletal muscle contraction IEP
IEP: 通过表达模式推断
15888549 RGD
involved in striated muscle cell differentiation IMP
IMP: 通过突变表型推断
11279241 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of IkappaB kinase complex IDA
IDA: 通过直接分析推断
17419723 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Chuk 蛋白结构

STKc_IKK_alpha

STKc_IKK_alpha: cd14039 (20 - 308)

Ubl_IKKA_like

Ubl_IKKA_like: cd17046 (310 - 386)

IKBKB_SDD

IKBKB_SDD: pfam18397 (385 - 658)

  • 0
  • 200
  • 400
  • 600
  • 758 a.a.
蛋白主名 其他名称

inhibitor of nuclear factor kappa-B kinase subunit alpha

conserved helix-loop-helix ubiquitous kinase

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02698 CHUK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02699 Chuk Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02700 Chuk Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chuk NCBI NCBI:1147
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