Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Gene

中文名称：磷脂酰肌醇 4 ,5-二磷酸 3-激酶催化亚基 γ

种属: Mus musculus

同用名: PI3Kgamma; p110gamma; p120-PI3K; 5830428L06Rik

关于 Pik3cg

功能概要

该基因编码的蛋白可启动 1-磷脂酰肌醇-3-激酶活性。参与多个过程，包括磷脂酰肌醇 3-激酶信号传导； Rac 蛋白信号转导的正调控；和鞘氨醇-1-磷酸受体信号通路。作用于多个过程的上游或内部，包括细胞对 cAMP 的反应；成纤维细胞凋亡过程的负调控；和调节钙离子跨膜转运。预测位于胞质溶胶中。预计是 IA 类磷脂酰肌醇 3-激酶复合物和 IB 类磷脂酰肌醇 3-激酶复合物的一部分。预计在细胞质和质膜中有活性。在淋巴系统和胸腺原基中表达。该基因的人类直系同源物与自闭症和猪流感有关。与人 PIK3CG（磷脂酰肌醇 4,5-二磷酸 3-激酶催化亚基 γ）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of Rac protein signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and regulation of calcium ion transmembrane transport. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]