STOML2 - stomatin like 2 Gene

中文名称：气孔样 2

种属: Homo sapiens

同用名: SLP-2; HSPC108

基因 ID: 30968 | 基因类型: protein coding

关于 STOML2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,099,776-35,103,195 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 27.8), heart (RPKM 26.8) and 25 other tissues.

功能概要

启用 GTPase 结合活性和心磷脂结合活性。参与多个过程，包括无机阳离子跨膜转运；心磷脂代谢过程的正向调节；和线粒体 DNA 复制的正调控。位于膜筏内；线粒体内膜；和线粒体膜间隙。是质膜的外在成分。与多种细胞成分共定位，包括 COP9 信号体； T 细胞受体复合体；和免疫突触。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase binding activity and cardiolipin binding activity. Involved in several processes, including inorganic cation transmembrane transport; positive regulation of cardiolipin metabolic process; and positive regulation of mitochondrial DNA replication. Located in membrane raft; mitochondrial inner membrane; and mitochondrial intermembrane space. Is extrinsic component of plasma membrane. Colocalizes with several cellular components, including COP9 signalosome; T cell receptor complex; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

STOML2 基因产物(4)

mRNA	Protein	Name
NM_001287031.2	NP_001273960.1	stomatin-like protein 2, mitochondrial isoform b
NM_001287032.1	NP_001273961.1	stomatin-like protein 2, mitochondrial isoform c
NM_001287033.2	NP_001273962.1	stomatin-like protein 2, mitochondrial isoform d
NM_013442.3	NP_038470.1	stomatin-like protein 2, mitochondrial isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase binding	IPI IPI: 通过物理相互作用推断	24337748	GOA
enables T cell receptor binding	IDA IDA: 通过直接分析推断	18641330	GOA
enables cardiolipin binding	IDA IDA: 通过直接分析推断	21746876	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17121834	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	18641330	GOA
involved in intracellular calcium ion homeostasis	IMP IMP: 通过突变表型推断	19944461	GOA
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	21746876	GOA
involved in protein complex oligomerization	IDA IDA: 通过直接分析推断	17121834	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin cytoskeleton	IDA IDA: 通过直接分析推断	18641330	GOA
located in immunological synapse	IDA IDA: 通过直接分析推断	22623988	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	18641330	GOA
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	17121834	GOA
located in mitochondrial intermembrane space	IDA IDA: 通过直接分析推断	17121834	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	22623988	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STOML2 蛋白结构

Band_7

0
100
200
300
356 a.a.

蛋白主名

其他名称

stomatin-like protein 2, mitochondrial

EPB72-like 2

STOML2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STOML2	Q9UJZ1	ATXN2	Homo sapiens	Q99700-5	Validated Y2H	32814053
种属内	STOML2	Q9UJZ1	ATXN2	Homo sapiens	Q99700-5	Y2H Array	32814053
种属内	STOML2	Q9UJZ1	ATXN2	Homo sapiens	Q99700-5	Y2H Pooling	32814053
种属内	STOML2	Q9UJZ1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	STOML2	Q9UJZ1	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	STOML2	Q9UJZ1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	STOML2	Q9UJZ1	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
种属内	STOML2	Q9UJZ1	PEX1	Homo sapiens	O43933	Y2H Array	32814053
种属内	STOML2	Q9UJZ1	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

STOML2 抗体

目录号	产品名	应用	反应物种
HY-P81975	SLP2 Antibody (YA1720)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-122671	OB-1	Inhibitor	99.12%	否
HY-122671S	OB-1-d3	Control	/	否
HY-RS13950	STOML2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	STOML2	VGNC	VGNC:35411
Rattus norvegicus	STOML2	RGD	RGD:1308285
Macaca mulatta	STOML2	VGNC	VGNC:78116
Mus musculus	STOML2	MGD	MGI:1913842
Felis catus	STOML2	VGNC	VGNC:65794

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