HLA-DOB - major histocompatibility complex, class II, DO beta Gene

中文名称：主要组织相容性复合体，II 类，DO beta

种属: Homo sapiens

同用名: DOB; HLA_DOB

关于 HLA-DOB

功能概要

HLA-DOB 属于 HLA II 类β链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DOA) 和一条 beta 链 (DOB) 组成，两者都锚定在膜中。它位于细胞内囊泡中。 DO 通过抑制 HLA-DM 来抑制 MHC II 类分子的肽负载。 II 类分子在抗原呈递细胞 (APC：B 淋巴细胞、树突细胞、巨噬细胞) 中表达。 β链约为 26-28 kDa，其基因包含 6 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域，外显子 5 编码细胞质尾部。[RefSeq 提供，2008 年 7 月]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]