Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

中文名称：zeste 2 多梳抑制复合物 2 亚基的增强子

种属: Rattus norvegicus

关于 Ezh2

功能概要

该基因编码的蛋白可启动染色质结合活性和转录顺式调节区结合活性。参与多个过程，包括组蛋白 H3-K27 甲基化；大分子代谢过程的负调控；和树突发育的正调控。位于细胞质和细胞核中。用于研究子宫内膜异位症。平滑肌瘤的生物标志物；非酒精性脂肪肝病；和胰腺癌。该基因的人类直系同源物与韦弗综合征有关；骨癌（多发性）；胃肠系统癌症（多发性）；血液系统癌症（多发性）；和肺癌。与人类 EZH2 同源（zeste 2 多梳抑制复合物 2 亚基的增强子）。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of macromolecule metabolic process; and positive regulation of dendrite development. Located in cytoplasm and nucleus. Used to study endometriosis. Biomarker of leiomyoma; non-alcoholic fatty liver disease; and pancreatic Cancer. Human ortholog(s) of this gene implicated in Weaver syndrome; bone Cancer (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung Cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]