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  2. HOXA4 - homeobox A4 Gene

HOXA4 - homeobox A4 Gene

中文名称:同源框 A4

种属: Homo sapiens

同用名: HOX1; HOX1D

基因 ID: 3201 | 基因类型: protein coding

关于 HOXA4

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,128,525-27,130,757 (from NCBI)

This gene has 4 transcripts (splice variants), 188 orthologues and 42 paralogues. Broad expression in esophagus (RPKM 4.4), lung (RPKM 4.1) and 19 other tissues.

功能概要

在脊椎动物中,编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。这些蛋白质的表达在胚胎发育过程中受到时空调控。该基因是 7 号染色体 A 簇的一部分,编码 DNA 结合转录因子,可调节基因表达、形态发生和分化。[RefSeq 提供,2008 年 7 月]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

HOXA4 基因产物(1)

mRNA Protein Name
NM_002141.5 NP_002132.3 homeobox protein Hox-A4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HOXA4 蛋白结构

Homeobox

Homeobox: Homeobox domain (216 - 272)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
蛋白主名 其他名称

homeobox protein Hox-A4

Dfd-like protein

关联疾病

疾病名称 别名
Athabaskan Brainstem Dysgenesis Syndrome

Bosley-Salih-Alorainy Syndrome

Navajo Brainstem Syndrome

ABDS

Human Hoxa1 Syndromes

BSAS

Athabaskan Brainstem Dysgenesis

Bosley Salih Alorainy Syndrome

Absd

Athabascan Brainstem Dysgenesis Syndrome

Narvajo Brainstem Syndrome

Hypospadias

Hypospadias Familial

Familial Hypospadias

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome

Hfgs

Hfg Syndrome

Hfu Syndrome

HFG

Hfu

Hand Foot Uterus Syndrome

Hand Foot Genital Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HOXA4 VGNC VGNC:41748
Mus musculus HOXA4 MGD MGI:96176
Bos taurus HOXA4 VGNC VGNC:29912
Felis catus HOXA4 VGNC VGNC:80596
Rattus norvegicus HOXA4 RGD RGD:2814
Macaca mulatta HOXA4 VGNC VGNC:81326